PIGM and LTB4R2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PIGM	LTB4R2
Description		phosphatidylinositol glycan anchor biosynthesis class M	leukotriene B4 receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Glycosylphosphatidylinositol-mannosyltransferase I Complex	Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Mannosyltransferase Activity GPI Mannosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Alpha-1,4-mannosyltransferase Activity Dol-P-Man:GlcN-acyl-PI Alpha-1,4-mannosyltransferase Activity	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	GPI Anchor Biosynthetic Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Leukotriene B4
Diseases		Glycosylphosphatidylinositol (GPI) deficiency
GWAS		Bipolar disorder ( 31043756)	Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		3 interacting genes: CHEK1 LTB4R2 PIGX	46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B
Entrez ID		93183	56413
HPRD ID		15133	16153
Ensembl ID		ENSG00000143315	ENSG00000213906
Uniprot IDs		Q9H3S5	B4E292 Q9NPC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G0 To G1 Transition Histone H3T11 Kinase Activity Regulation Of Mitotic Centrosome Separation Leukotriene Signaling Pathway Keratinocyte Migration Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Mitotic Nuclear Membrane Disassembly Negative Regulation Of Adenylate Cyclase Activity Membrane Disassembly Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence Replication Fork Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Nuclear Envelope Organization GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Apoptotic Process Involved In Development Positive Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Epithelial Cell Migration	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B
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