VPS4A and CHMP1A

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		VPS4A	CHMP1A
Gene Name		vacuolar protein sorting 4 homolog A (S. cerevisiae)	charged multivesicular body protein 1A
Image
Gene Ontology Annotations	Cellular Component	ESCRT III Complex Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Flemming Body	Condensed Nuclear Chromosome ESCRT III Complex Early Endosome Microtubule Organizing Center Endomembrane System Nuclear Matrix Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled	Protein Binding Metallopeptidase Activity Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Cytokinesis Cell Separation After Cytokinesis Nucleus Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Protein Transport Viral Process Vesicle-mediated Transport Endosomal Transport Viral Life Cycle Cytoplasmic Microtubule Organization Negative Regulation Of Cytokinesis Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion	Cytokinesis Cell Separation After Cytokinesis Transcription, DNA-templated Proteolysis Nucleus Organization Vacuolar Transport Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Vesicle-mediated Transport Gene Silencing Negative Regulation Of Transcription By Glucose Negative Regulation Of Transcription, DNA-templated Regulation Of Mitotic Spindle Assembly
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C NPC1 RND2 VPS4B	9 interactors: CHMP1B KIAA1715 NR1I2 STAMBP UBE2I USP8 VPS4A VPS4B ZDHHC17
Entrez ID		27183	5119
HPRD ID		11676	01237
Ensembl ID		ENSG00000132612	ENSG00000131165
Uniprot IDs		Q9UN37	A6NG32 Q9HD42
PDB IDs		1YXR 2JQ9 2K3W	2JQ9 2YMB 4A5X
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Mitotic Metaphase Plate Congression Regulation Of Spindle Assembly Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Regulation Of Centrosome Duplication Nucleus Organization Regulation Of Centrosome Cycle Viral Budding Via Host ESCRT Complex Chromosome Segregation Positive Regulation Of Viral Release From Host Cell Viral Budding Regulation Of Mitotic Nuclear Division Mitotic Nuclear Division Establishment Of Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Organelle Localization Cell Division Regulation Of Viral Release From Host Cell Virion Assembly Regulation Of Cell Division Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Process Regulation Of Protein Complex Assembly Mitotic Cell Cycle Establishment Of Protein Localization Regulation Of Mitotic Cell Cycle Intracellular Transport Viral Life Cycle Regulation Of Organelle Organization Regulation Of Cell Cycle Process Endosomal Transport Regulation Of Cytoskeleton Organization Chromosome Organization Positive Regulation Of Viral Process Cell Cycle Process Negative Regulation Of Macroautophagy Membrane Budding Protein Localization Regulation Of Cellular Component Organization Establishment Of Localization In Cell Cell Cycle Protein Transport Cellular Localization	Cell Division Cell Separation After Cytokinesis Mitotic Cell Cycle Process Cytokinesis Mitotic Cell Cycle Mitotic Metaphase Plate Congression Metaphase Plate Congression Establishment Of Chromosome Localization Cell Cycle Process Chromosome Segregation Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Cell Cycle Mitotic Sister Chromatid Segregation Mitotic Nuclear Division Regulation Of Mitotic Spindle Assembly Sister Chromatid Segregation Viral Budding Regulation Of Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Nucleus Organization Regulation Of Mitotic Spindle Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Protein Catabolic Process Protein Catabolic Process Endosome Organization Regulation Of Cell Division Proteolysis Regulation Of Centrosome Duplication Mitotic Cytokinesis Regulation Of Centrosome Cycle Cellular Macromolecule Catabolic Process Establishment Of Organelle Localization Positive Regulation Of Exocytosis Catabolic Process Drug Export Negative Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation Positive Regulation Of SUMO Transferase Activity Membrane Budding Organelle Localization Regulation Of Cell Cycle Process Vacuole Organization Protein Deubiquitination Positive Regulation Of Centriole Replication
Tagcloud ?		aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww	aux1 auxin disorganized endosomal escrt gradients internalized lip5 lumenal meristems mislocalized multivesicular mvb mvbs pin1 pin2 pinformed1 protein1a resistant1 rudimentary seedling seedlings skd1 sorted stomata symmetry thaliana vacuolar
Tagcloud (Difference) ?		aip1 budding detail dn e3 gag htlv infant invagination mother motif nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww	aux1 auxin disorganized endosomal gradients internalized lip5 lumenal meristems mislocalized mvbs pin1 pin2 pinformed1 protein1a resistant1 rudimentary seedling seedlings skd1 sorted stomata symmetry thaliana vacuolar
Tagcloud (Intersection) ?		escrt multivesicular mvb