VPS4A and CHMP2A

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
HPRD (two hybrid)

		VPS4A	CHMP2A
Gene Name		vacuolar protein sorting 4 homolog A (S. cerevisiae)	charged multivesicular body protein 2A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT III Complex Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Flemming Body	Cytosol Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled	Protein Binding Protein Domain Specific Binding
	Biological Process	Cytokinesis Cell Separation After Cytokinesis Nucleus Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Protein Transport Viral Process Vesicle-mediated Transport Endosomal Transport Viral Life Cycle Cytoplasmic Microtubule Organization Negative Regulation Of Cytokinesis Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization Regulation Of Viral Process Negative Regulation Of Cell Death Membrane Organization Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C NPC1 RND2 VPS4B	12 interactors: CHMP3 DOCK8 E2F4 EIF2B5 MITD1 NOL4 STAMBP TGFB3 USP54 USP8 VPS4A VPS4B
Entrez ID		27183	27243
HPRD ID		11676	12520
Ensembl ID		ENSG00000132612	ENSG00000130724
Uniprot IDs		Q9UN37	O43633
PDB IDs		1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Mitotic Metaphase Plate Congression Regulation Of Spindle Assembly Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Regulation Of Centrosome Duplication Nucleus Organization Regulation Of Centrosome Cycle Viral Budding Via Host ESCRT Complex Chromosome Segregation Positive Regulation Of Viral Release From Host Cell Viral Budding Regulation Of Mitotic Nuclear Division Mitotic Nuclear Division Establishment Of Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Organelle Localization Cell Division Regulation Of Viral Release From Host Cell Virion Assembly Regulation Of Cell Division Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Process Regulation Of Protein Complex Assembly Mitotic Cell Cycle Establishment Of Protein Localization Regulation Of Mitotic Cell Cycle Intracellular Transport Viral Life Cycle Regulation Of Organelle Organization Regulation Of Cell Cycle Process Endosomal Transport Regulation Of Cytoskeleton Organization Chromosome Organization Positive Regulation Of Viral Process Cell Cycle Process Negative Regulation Of Macroautophagy Membrane Budding Protein Localization Regulation Of Cellular Component Organization Establishment Of Localization In Cell Cell Cycle Protein Transport Cellular Localization	Cell Separation After Cytokinesis Cell Division Cytokinesis Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cytokinesis Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Cycle Process Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Release From Host Cell Viral Budding Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cell Cycle Regulation Of Viral Release From Host Cell Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Endosome Organization Metaphase Plate Congression Endosomal Transport Protein Catabolic Process Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Cell Division Regulation Of Centrosome Cycle Proteolysis Positive Regulation Of Exocytosis Positive Regulation Of Secretion Cellular Macromolecule Catabolic Process Negative Regulation Of Exosomal Secretion Memory T Cell Proliferation Positive Regulation Of Centriole Elongation Positive Regulation Of Viral Process Mitotic Sister Chromatid Segregation Membrane Budding Sister Chromatid Segregation Negative Regulation Of Cell Death Positive Regulation Of Centriole Replication Detection Of Hypoxia Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Uterine Wall Breakdown Ovulation Cycle Process Vacuole Organization Protein Deubiquitination
Tagcloud ?		aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww
Tagcloud (Difference) ?		aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww
Tagcloud (Intersection) ?