VPS4A and VPS4B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		VPS4A	VPS4B
Description		vacuolar protein sorting 4 homolog A	vacuolar protein sorting 4 homolog B
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nuclear Pore Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body ATPase Complex	Spindle Pole Nucleus Nuclear Pore Cytoplasm Endosome Centrosome Cytosol Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome Flemming Body ATPase Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding ATP-dependent Protein Disaggregase Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Actomyosin Contractile Ring Contraction Plasma Membrane Repair Protein Targeting To Lysosome Vesicle Budding From Membrane Autophagy Nucleus Organization Nuclear Envelope Organization Endosome Organization Vacuole Organization Lysosomal Transport Mitotic Metaphase Chromosome Alignment Mitotic Nuclear Membrane Reassembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Signaling Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Vesicle Uncoating Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex ESCRT Complex Disassembly ESCRT III Complex Disassembly	Angiogenesis Plasma Membrane Repair Potassium Ion Transport Autophagy Nucleus Organization Endosome Organization Vacuole Organization Vacuolar Transport Lysosomal Transport Mitotic Metaphase Chromosome Alignment Central Nervous System Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Cholesterol Transport Nuclear Membrane Reassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Canonical Wnt Signaling Pathway Establishment Of Blood-brain Barrier Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		13 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 OGT RND2 SNCA VPS4B	10 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 OGT VPS4A ZFYVE19
Entrez ID		27183	9525
HPRD ID		11676	15653
Ensembl ID		ENSG00000132612	ENSG00000119541
Uniprot IDs		Q9UN37	O75351
PDB IDs		1YXR 2JQ9 2K3W	1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y 7L9X
Enriched GO Terms of Interacting Partners?		Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Multivesicular Body Assembly Multivesicular Body Organization Regulation Of Spindle Assembly Lysosomal Membrane Organization Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Kinetochore Microtubule Nuclear Membrane Organization Autophagosome Maturation Metaphase Chromosome Alignment Membrane Assembly Lysosomal Transport Multivesicular Body Membrane Chromosome Localization Biological Process Involved In Interaction With Host Endosome Organization Regulation Of Microtubule Cytoskeleton Organization Nuclear Pore Vacuolar Transport Autophagy Nucleus Organization Multivesicular Body Regulation Of Centrosome Duplication Autophagosome Membrane Plasma Membrane Organization Regulation Of Centrosome Cycle Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Viral Process Organelle Localization	Midbody Abscission Mitotic Cytokinetic Process ESCRT III Complex Disassembly ESCRT Complex Disassembly Cytokinetic Process Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Viral Budding Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Membrane Fission Multivesicular Body-lysosome Fusion Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Lysosomal Membrane Organization Metaphase Chromosome Alignment Membrane Assembly Midbody Kinetochore Microtubule Chromosome Localization Regulation Of Mitotic Spindle Assembly Endosome Organization Nuclear Pore Nucleus Organization Multivesicular Body Membrane Vesicle Fusion Organelle Membrane Fusion Regulation Of Spindle Assembly Plasma Membrane Organization Lysosomal Transport Autophagy Organelle Fusion Regulation Of Mitotic Spindle Organization Protein-containing Complex Disassembly Multivesicular Body Viral Process Regulation Of Centrosome Duplication Membrane Fusion
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