VPS4A and CHMP4A

Number of citations of the paper that reports this interaction (PMID 12860994)
56

Data Source:
HPRD (two hybrid, in vivo)

		VPS4A	CHMP4A
Gene Name		vacuolar protein sorting 4 homolog A (S. cerevisiae)	charged multivesicular body protein 4A
Image
Gene Ontology Annotations	Cellular Component	ESCRT III Complex Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Flemming Body	ESCRT III Complex Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Midbody Cytoplasmic Vesicle Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity ATPase Binding
	Biological Process	Cytokinesis Cell Separation After Cytokinesis Nucleus Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Protein Transport Viral Process Vesicle-mediated Transport Endosomal Transport Viral Life Cycle Cytoplasmic Microtubule Organization Negative Regulation Of Cytokinesis Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion	Cell Separation After Cytokinesis Posttranslational Protein Targeting To Membrane Membrane Budding Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Viral Process Endosomal Transport Viral Life Cycle Viral Budding Via Host ESCRT Complex Protein Homooligomerization Membrane Organization Membrane Tubulation Negative Regulation Of Neuron Death Negative Regulation Of Autophagic Vacuole Assembly
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C NPC1 RND2 VPS4B	12 interactors: CC2D1A CDK13 CHMP3 CHMP4B CHMP4C CHMP5 CHMP6 PDCD6IP STAMBP SYT17 TTC19 VPS4A
Entrez ID		27183	29082
HPRD ID		11676	16597
Ensembl ID		ENSG00000132612	ENSG00000254505
Uniprot IDs		Q9UN37	Q14D22 Q9BY43
PDB IDs		1YXR 2JQ9 2K3W	3C3O
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Mitotic Metaphase Plate Congression Regulation Of Spindle Assembly Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Regulation Of Centrosome Duplication Nucleus Organization Regulation Of Centrosome Cycle Viral Budding Via Host ESCRT Complex Chromosome Segregation Positive Regulation Of Viral Release From Host Cell Viral Budding Regulation Of Mitotic Nuclear Division Mitotic Nuclear Division Establishment Of Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Organelle Localization Cell Division Regulation Of Viral Release From Host Cell Virion Assembly Regulation Of Cell Division Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Process Regulation Of Protein Complex Assembly Mitotic Cell Cycle Establishment Of Protein Localization Regulation Of Mitotic Cell Cycle Intracellular Transport Viral Life Cycle Regulation Of Organelle Organization Regulation Of Cell Cycle Process Endosomal Transport Regulation Of Cytoskeleton Organization Chromosome Organization Positive Regulation Of Viral Process Cell Cycle Process Negative Regulation Of Macroautophagy Membrane Budding Protein Localization Regulation Of Cellular Component Organization Establishment Of Localization In Cell Cell Cycle Protein Transport Cellular Localization	Cell Separation After Cytokinesis Cell Division Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Metaphase Plate Congression Viral Life Cycle Metaphase Plate Congression Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Centrosome Cycle Viral Process Vacuolar Transport Mitotic Sister Chromatid Segregation Endosomal Transport Sister Chromatid Segregation Regulation Of Cell Cycle Process Nucleus Organization Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Release From Host Cell Regulation Of Mitotic Spindle Assembly Regulation Of Microtubule Cytoskeleton Organization Viral Budding Regulation Of Spindle Assembly Regulation Of Microtubule-based Process Regulation Of Mitotic Spindle Organization Membrane Organization Chromosome Segregation Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Viral Release From Host Cell Virion Assembly Cell Cycle Process Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Establishment Of Organelle Localization Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Organelle Localization Protein Transport Establishment Of Protein Localization Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Abscission Positive Regulation Of Viral Process Membrane Budding Negative Regulation Of Cytokinesis Protein Localization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Establishment Of Localization In Cell
Tagcloud ?		aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww
Tagcloud (Difference) ?		aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww
Tagcloud (Intersection) ?