CD247 and TIRAP

Number of citations of the paper that reports this interaction (PMID 11572860)
16

Data Source:
HPRD (in vivo)

		CD247	TIRAP
Gene Name		CD247 molecule	toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane Intercellular Bridge
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Binding, Bridging Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways			Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	25 interactors: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1
Entrez ID		919	114609
HPRD ID		01729	05878
Ensembl ID		ENSG00000198821	ENSG00000150455
Uniprot IDs		P20963	P58753
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ	2Y92 3UB2 3UB3 3UB4 4FZ5
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation	Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Immune Response Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Biotic Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Other Organism Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune Response Response To Organic Substance Cellular Response To Organic Substance Regulation Of Chemokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process Response To External Stimulus Cell Communication Response To Molecule Of Bacterial Origin TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth	7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr
Tagcloud (Difference) ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth	7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr
Tagcloud (Intersection) ?