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CD247 and TIRAP
Number of citations of the paper that reports this interaction (PubMedID
11572860
)
0
Data Source:
HPRD
(in vivo)
CD247
TIRAP
Description
CD247 molecule
TIR domain containing adaptor protein
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Membrane
Fc-gamma Receptor III Complex
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Gamma-delta T Cell Receptor Complex
Plasma Membrane Protein Complex
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Membrane
Endocytic Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Tyrosine Kinase Binding
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Identical Protein Binding
Molecular Adaptor Activity
Biological Process
Adaptive Immune Response
Immune System Process
Cell Surface Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Gamma-delta T Cell Activation
Alpha-beta T Cell Activation
T Cell Receptor Signaling Pathway
Protein Complex Oligomerization
Protein-containing Complex Assembly
Positive Regulation Of Protein Localization To Cell Surface
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein-containing Complex Assembly
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Drugs
Muromonab
Teclistamab
Odronextamab
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
31361310
)
Asthma (
34103634
31361310
31619474
31959851
32296059
30929738
27182965
)
Asthma (adult onset) (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma (moderate or severe) (
30552067
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Autoimmune thyroid disease (
32581359
)
Celiac disease (
20190752
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Medication use (glucocorticoids) (
31015401
)
Medication use (thyroid preparations) (
31015401
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Systemic sclerosis (
31672989
29293537
21779181
21750679
20383147
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Interacting Genes
38 interacting genes:
CD2
CD244
CD28
CD3D
CD48
CD5
CSK
DOCK2
FCGR3A
FYN
GAB2
GRB2
JAK3
LCK
LY6E
NCR1
NCR3
PCGF2
PI4K2B
PTPN22
PTPN3
PTPN6
PTPRC
SH2B3
SHC1
SLA
SLA2
STAT5A
STAT5B
TFRC
TIRAP
TRA
TRAT1
TRB
UNC119
VTN
ZAP70
ZNF281
25 interacting genes:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK2
IRAK4
LRRK1
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
Entrez ID
919
114609
HPRD ID
01729
05878
Ensembl ID
ENSG00000198821
ENSG00000150455
Uniprot IDs
A0A8V8TPP4
A0A8V8TQM0
P20963
Q6KAV0
P58753
PDB IDs
1TCE
1YGR
2HAC
2OQ1
3IK5
3IOZ
4XZ1
6JXR
7FJD
7FJE
7FJF
7PHR
8ES7
8ES8
8ES9
8J8I
8JC0
8JCB
8TW4
8TW6
8WXE
8WY0
8WYI
8YC0
9BBC
9C3E
9CI8
9CIA
9CQ4
2NDH
2Y92
3UB2
3UB3
3UB4
4FZ5
4LQD
5T7Q
5UZB
8JZM
Enriched GO Terms of Interacting Partners
?
Lymphocyte Activation
Immune System Process
Leukocyte Activation
Cell Activation
Signal Transduction
Positive Regulation Of Immune System Process
Natural Killer Cell Activation
T Cell Activation
Regulation Of Lymphocyte Activation
Immune Response
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Activation
Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Immune Response-activating Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Plasma Membrane
T Cell Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Cell Adhesion
Lymphocyte Mediated Immunity
Positive Regulation Of Cell-cell Adhesion
Leukocyte Mediated Cytotoxicity
T Cell Costimulation
Phosphotyrosine Residue Binding
Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Mediated Immunity
Immune Effector Process
Positive Regulation Of Cell Adhesion
Adaptive Immune Response
Regulation Of Mononuclear Cell Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Leukocyte Proliferation
Regulation Of Lymphocyte Mediated Immunity
T Cell Receptor Complex
Natural Killer Cell Mediated Immunity
Alpha-beta T Cell Receptor Complex
Toll-like Receptor Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Chemokine Production
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Defense Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Regulation Of Chemokine Production
Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Defense Response
Innate Immune Response
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Cytokine Production
Response To Other Organism
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Intracellular Signal Transduction
Immune Response
Defense Response To Symbiont
Defense Response To Virus
Defense Response To Other Organism
Interleukin-33-mediated Signaling Pathway
Immune System Process
Interleukin-1-mediated Signaling Pathway
Regulation Of Cytokine Production
Regulation Of Immune System Process
Response To External Biotic Stimulus
Response To Stress
Regulation Of Type I Interferon Production
Positive Regulation Of Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Interleukin-6 Production
Response To Virus
MyD88-independent Toll-like Receptor Signaling Pathway
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Tagcloud (Intersection)
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