TIRAP and MPP3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TIRAP	MPP3
Gene Name		toll-interleukin 1 receptor (TIR) domain containing adaptor protein	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane Intercellular Bridge	Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Binding, Bridging Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Guanylate Kinase Activity PDZ Domain Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Signal Transduction Nucleotide Phosphorylation
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1	33 interactors: APP ARL2BP CADM1 CCDC137 CRABP1 ERBB2IP EZR FAM171B GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZPR1
Entrez ID		114609	4356
HPRD ID		05878	03069
Ensembl ID		ENSG00000150455	ENSG00000161647
Uniprot IDs		P58753	Q13368
PDB IDs		2Y92 3UB2 3UB3 3UB4 4FZ5
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Immune Response Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Biotic Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Other Organism Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune Response Response To Organic Substance Cellular Response To Organic Substance Regulation Of Chemokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process Response To External Stimulus Cell Communication Response To Molecule Of Bacterial Origin TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway	Regulation Of Protein Binding Cell Growth Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Binding Regulation Of Protein Homodimerization Activity Growth Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle MRNA Metabolic Process Positive Regulation Of Binding Cellular Response To Epidermal Growth Factor Stimulus Multicellular Organismal Development Asymmetric Protein Localization System Development Establishment Or Maintenance Of Apical/basal Cell Polarity RNA Processing DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Signal Transduction Response To Epidermal Growth Factor DNA Strand Elongation Organelle Organization Exocytosis RNA Splicing Signaling Cellular Protein Localization G1/S Transition Of Mitotic Cell Cycle Cell Communication Nervous System Development Receptor Internalization Cellular Component Assembly Positive Regulation Of Interleukin-15 Production Nuclear Speck Organization Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Neurotrophin Production Dermatan Sulfate Catabolic Process Positive Regulation Of Nonmotile Primary Cilium Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Pre-mRNA Catabolic Process DNA Endoreduplication Signal Transduction Positive Regulation Of Innate Immune Response Protein Localization Regulation Of Phosphorus Metabolic Process
Tagcloud ?		7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr	17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue
Tagcloud (Difference) ?		7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr	17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue
Tagcloud (Intersection) ?