CD247 and NCR3

Number of citations of the paper that reports this interaction (PubMedID 12731048)
0

Data Source:
HPRD (in vitro, in vivo)

		CD247	NCR3
Description		CD247 molecule	natural cytotoxicity triggering receptor 3
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding	Protein Binding Identical Protein Binding Immune Receptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Inflammatory Response Immune Response Cell Recognition Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity NK T Cell Activation
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Muromonab Teclistamab Odronextamab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Appendicular lean mass ( 33097823) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 30226566) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213) Malaria ( 31844061) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 19079260)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	5 interacting genes: BAG6 CD247 CD59 FAM209A FCER1G
Entrez ID		919	259197
HPRD ID		01729	11384
Ensembl ID		ENSG00000198821	ENSG00000204475
Uniprot IDs		A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0	O14931 Q05D23
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4	3NOI 3PV6 6YJP 9FWW
Enriched GO Terms of Interacting Partners?		Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex	Fc-gamma Receptor III Complex Activation Of Immune Response Positive Regulation Of Immune Response Plasma Membrane Protein Complex Positive Regulation Of Protein Localization To Cell Surface Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface T Cell Activation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Tertiary Granule Membrane Lymphocyte Activation IgE Receptor Activity Leukocyte Activation Alpha-beta T Cell Activation Regulation Of Immune System Process Cell Activation Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Immune System Process Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Receptor Complex Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Positive Regulation Of Type III Hypersensitivity BAT3 Complex Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Maintenance Of Unfolded Protein Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Transmembrane Signaling Receptor Activity Alpha-beta T Cell Receptor Complex Complement Binding Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Internal Peptidyl-lysine Acetylation NK T Cell Activation
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