CD247 and PI4K2B

Number of citations of the paper that reports this interaction (PubMedID 16337488)
0

Data Source:
HPRD (in vivo, in vitro)

		CD247	PI4K2B
Description		CD247 molecule	phosphatidylinositol 4-kinase type 2 beta
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex	Golgi Membrane Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding	Nucleotide Binding 1-phosphatidylinositol 4-kinase Activity ATP Binding Kinase Activity Transferase Activity
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphate Biosynthetic Process
Pathways			Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
Drugs		Muromonab Teclistamab Odronextamab	Resveratrol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147)	Attention deficit hyperactivity disorder ( 30563984) Cannabis dependence symptom count ( 27028160) Logical memory (immediate recall) in normal cognition ( 29274321) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	4 interacting genes: AKT1 CASR CD247 MAPK14
Entrez ID		919	55300
HPRD ID		01729	15132
Ensembl ID		ENSG00000198821	ENSG00000038210
Uniprot IDs		A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0	G5E9Z4 Q8TCG2
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4	4WTV 8A5X
Enriched GO Terms of Interacting Partners?		Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex	Positive Regulation Of Protein Localization Cellular Response To Peptide Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Surface Cellular Response To Lipoprotein Particle Stimulus Regulation Of Protein Localization To Cell Surface Positive Regulation Of D-glucose Import Response To Growth Factor Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Organ Growth Regulation Of D-glucose Import Cellular Response To Lipid Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Nutrient Levels Positive Regulation Of Fat Cell Differentiation Striated Muscle Cell Differentiation Regulation Of D-glucose Transmembrane Transport Response To Peptide RNA Stabilization Glutamatergic Synapse Positive Regulation Of Locomotion Negative Regulation Of RNA Catabolic Process Regulation Of Organ Growth Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Muscle Cell Differentiation Regulation Of TRNA Methylation Protein Homodimerization Activity Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Response To Tumor Necrosis Factor Glucose Metabolic Process Osteoblast Differentiation Response To Calcium Ion Regulation Of Fat Cell Differentiation Response To Lipid Cellular Response To Decreased Oxygen Levels Positive Regulation Of Transport Positive Regulation Of Protein Localization To Endoplasmic Reticulum Cellular Response To Oxygen Levels Response To Insulin-like Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Immune Response Positive Regulation Of Cell Population Proliferation Mammalian Oogenesis Stage Response To UV
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