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TIRAP and LTN1
Number of citations of the paper that reports this interaction (PubMedID
21903422
)
55
Data Source:
BioGRID
(pull down)
TIRAP
LTN1
Description
TIR domain containing adaptor protein
listerin E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Membrane
Endocytic Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Cytoplasm
Cytosol
Cytosolic Ribosome
RQC Complex
Molecular Function
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Identical Protein Binding
Molecular Adaptor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Ribosomal Large Subunit Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein-containing Complex Assembly
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Protein Ubiquitination
Protein Autoubiquitination
Rescue Of Stalled Ribosome
Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Antigen processing: Ubiquitination & Proteasome degradation
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Hip circumference (
28552196
)
Immature fraction of reticulocytes (
32888494
)
Initial pursuit acceleration in psychotic disorders (
29064472
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Interacting Genes
25 interacting genes:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK2
IRAK4
LRRK1
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
9 interacting genes:
AGO1
HES4
IRF7
STING1
TIRAP
UBC
UBE2D1
UBE2D2
UBE2L3
Entrez ID
114609
26046
HPRD ID
05878
10327
Ensembl ID
ENSG00000150455
ENSG00000198862
Uniprot IDs
P58753
O94822
PDB IDs
2NDH
2Y92
3UB2
3UB3
3UB4
4FZ5
4LQD
5T7Q
5UZB
8JZM
3J92
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Chemokine Production
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Defense Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Regulation Of Chemokine Production
Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Defense Response
Innate Immune Response
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Cytokine Production
Response To Other Organism
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Intracellular Signal Transduction
Immune Response
Defense Response To Symbiont
Defense Response To Virus
Defense Response To Other Organism
Interleukin-33-mediated Signaling Pathway
Immune System Process
Interleukin-1-mediated Signaling Pathway
Regulation Of Cytokine Production
Regulation Of Immune System Process
Response To External Biotic Stimulus
Response To Stress
Regulation Of Type I Interferon Production
Positive Regulation Of Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Interleukin-6 Production
Response To Virus
MyD88-independent Toll-like Receptor Signaling Pathway
Ubiquitin Conjugating Enzyme Activity
Regulation Of Interferon-beta Production
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Type I Interferon Production
Post-translational Protein Modification
Regulation Of RNA Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Nucleoplasm
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Interferon-beta Production
Activation Of Innate Immune Response
Catabolic Process
Protein Ubiquitination
Proteolysis
Modification-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Positive Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Innate Immune Response
Regulation Of RNA Biosynthetic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Modification By Small Protein Conjugation
Protein Polyubiquitination
Ubiquitin-protein Transferase Activity
Transcription Coactivator Activity
Positive Regulation Of Ribosome Biogenesis
Positive Regulation Of Pattern Recognition Receptor Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Interleukin-15 Production
Cyclic-di-GMP Binding
STING Complex
Positive Regulation Of Response To Cytokine Stimulus
Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Immune Response-activating Signaling Pathway
Signaling Adaptor Activity
Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Primary Metabolic Process
Establishment Of Viral Latency
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
2',3'-cyclic GMP-AMP Binding
Positive Regulation Of Type I Interferon Production
Protein Modification Process
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