CD247 and ZNF281

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CD247	ZNF281
Gene Name		CD247 molecule	zinc finger protein 281
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Nucleus Nucleoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Embryonic Body Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	4 interactors: CD247 EGLN1 MYC ZBTB16
Entrez ID		919	23528
HPRD ID		01729	11702
Ensembl ID		ENSG00000198821	ENSG00000162702
Uniprot IDs		P20963	A6NF48 B3KMX4 Q9Y2X9
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation	Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Mesonephros Development Regulation Of Myeloid Cell Differentiation Fibroblast Apoptotic Process Negative Regulation Of CAMP Catabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Immune System Process Positive Regulation Of NK T Cell Differentiation Regulation Of T Cell Activation Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Cell Activation Kidney Development Negative Regulation Of Monocyte Differentiation Positive Regulation Of Cell Proliferation Involved In Kidney Development Renal System Development Oxygen Homeostasis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Tissue Development Urogenital System Development Regulation Of Lymphocyte Activation Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of Cellular Metabolic Process Response To Nitric Oxide Heart Trabecula Formation Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process 4-hydroxyproline Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Defense Response To Virus By Virus Oxygen Transport Tissue Morphogenesis Peptidyl-proline Hydroxylation Negative Regulation Of Cell Proliferation Heart Trabecula Morphogenesis Protein Hydroxylation Positive Regulation Of Chondrocyte Differentiation
Tagcloud ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth	34a accordingly cd133 circuitry crc deregulation ectopic emt feed finger forward kruppel lgr5 microrna mutational nanog oct4 organismal physically pluripotency snail sox2 sphere stemness suppressive tf translated zbp zfp148
Tagcloud (Difference) ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth	34a accordingly cd133 circuitry crc deregulation ectopic emt feed finger forward kruppel lgr5 microrna mutational nanog oct4 organismal physically pluripotency snail sox2 sphere stemness suppressive tf translated zbp zfp148
Tagcloud (Intersection) ?