CD247 and ZNF281

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CD247	ZNF281
Description		CD247 molecule	zinc finger protein 281
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex	Nucleus Nucleoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Embryonic Body Morphogenesis Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Stem Cell Differentiation
Pathways
Drugs		Muromonab Teclistamab Odronextamab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147)	Antisaccade task score ( 31596458) Myopia ( 27182965) Neurofibrillary tangles ( 31497858) Prepulse inhibition of the startle response ( 31596458) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	7 interacting genes: CD247 EGLN1 FBXW11 MYC PIK3R3 STAT3 ZBTB16
Entrez ID		919	23528
HPRD ID		01729	11702
Ensembl ID		ENSG00000198821	ENSG00000162702
Uniprot IDs		A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0	B3KMX4 Q9Y2X9
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex	Cell Surface Receptor Signaling Pathway T Cell Activation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Oxygen Levels Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Transcription Intracellular Iron Ion Homeostasis Negative Regulation Of Intracellular Signal Transduction Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Protein Dimerization Activity Positive Regulation Of Acinar Cell Proliferation Positive Regulation Of DNA-templated Transcription SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Hypoxia Regulation Of Hemopoiesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of MiRNA Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Alpha-beta T Cell Activation Lymphocyte Activation Negative Regulation Of Myeloid Cell Differentiation Myc-Max Complex Regulation Of Acinar Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Type 2 Angiotensin Receptor Binding Peptidyl-proline Dioxygenase Activity Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Leukocyte Activation Fc-gamma Receptor III Complex Gamma-delta T Cell Receptor Complex NK T Cell Proliferation Regulation Of Cellular Response To Stress Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Male Germ-line Stem Cell Asymmetric Division Regulation Protein Catabolic Process At Postsynapse
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