TIRAP and CASP1

Number of citations of the paper that reports this interaction (PMID 20048342)
7

Data Source:
BioGRID (enzymatic study)

		TIRAP	CASP1
Gene Name		toll-interleukin 1 receptor (TIR) domain containing adaptor protein	caspase 1, apoptosis-related cysteine peptidase
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane Intercellular Bridge	Extracellular Region Cytoplasm Cytosol IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Binding, Bridging Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Response To Hypoxia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Autophagy Response To Lipopolysaccharide Interleukin-1 Beta Production Response To ATP Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Mitochondrial Depolarization Membrane Hyperpolarization Pyroptosis Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Execution Phase Of Apoptosis Programmed Necrotic Cell Death Toxin Transport
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	Signaling by Interleukins The NLRP3 inflammasome Inflammasomes NOD1/2 Signaling Pathway The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Interleukin-1 processing The IPAF inflammasome Cytokine Signaling in Immune system Innate Immune System
Drugs			Minocycline 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1	42 interactors: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17 CARD8 CASP10 CASP14 CASP4 CASP8 CAST CDK11B EGFR FGF2 HTT IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARK2 PARP1 PLA2G4A PLA2G4B PSEN1 PSEN2 PYCARD RIPK2 TFAP2A TIRAP VAC14
Entrez ID		114609	834
HPRD ID		05878	00977
Ensembl ID		ENSG00000150455	ENSG00000137752
Uniprot IDs		P58753	A8K249 A8K257 P29466
PDB IDs		2Y92 3UB2 3UB3 3UB4 4FZ5	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Immune Response Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Biotic Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Other Organism Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune Response Response To Organic Substance Cellular Response To Organic Substance Regulation Of Chemokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process Response To External Stimulus Cell Communication Response To Molecule Of Bacterial Origin TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway	Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Response To Stress Immune Response Signaling Regulation Of Signaling Cell Communication Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Proteolysis Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Cell Death Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Localization Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Immune System Process Signal Transduction Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Protein Processing Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Positive Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?