CD247 and CD48

Number of citations of the paper that reports this interaction (PubMedID 16049493)
0

Data Source:
HPRD (in vitro)

		CD247	CD48
Description		CD247 molecule	CD48 molecule
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding	Protein Binding Receptor Ligand Activity
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation
Pathways			Cell surface interactions at the vascular wall
Drugs		Muromonab Teclistamab Odronextamab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK
Entrez ID		919	962
HPRD ID		01729	00177
Ensembl ID		ENSG00000198821	ENSG00000117091
Uniprot IDs		A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0	A0A087X1S7 P09326
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4	2EDO
Enriched GO Terms of Interacting Partners?		Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex	Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process
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