CD247 and CD48

Number of citations of the paper that reports this interaction (PMID 16049493)
63

Data Source:
HPRD (in vitro)

		CD247	CD48
Gene Name		CD247 molecule	CD48 molecule
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	Receptor Activity Protein Binding
	Biological Process	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway	Defense Response Blood Coagulation Leukocyte Migration
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	10 interactors: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK
Entrez ID		919	962
HPRD ID		01729	00177
Ensembl ID		ENSG00000198821	ENSG00000117091
Uniprot IDs		P20963	P09326
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ	2EDO
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation	Regulation Of Defense Response To Virus By Virus Blood Coagulation Hemostasis Leukocyte Migration Regulation Of Body Fluid Levels Wound Healing T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation T Cell Costimulation Cell Activation Regulation Of T Cell Activation Regulation Of Defense Response To Virus Positive Regulation Of Cell Activation Immune System Process Response To Wounding Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Signaling Antigen Receptor-mediated Signaling Pathway Cell Communication Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Platelet Activation Cellular Response To Stimulus Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Response To Stress Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Positive Regulation Of Intracellular Signal Transduction Cell Migration Natural Killer Cell Activation Cell Motility Positive Regulation Of Immune System Process
Tagcloud ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth	advance cd150 cdd committed doi effector epo epor erythroblasts erythrocytes erythroid erythropoiesis erythropoietin h2afy2 highlighted hscs immunophenotypically lin macroh2a2 mh2a2 november phospholipase plcgamma1 progenitors publication recapitulated sca1 stat5a tightly
Tagcloud (Difference) ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth	advance cd150 cdd committed doi effector epo epor erythroblasts erythrocytes erythroid erythropoiesis erythropoietin h2afy2 highlighted hscs immunophenotypically lin macroh2a2 mh2a2 november phospholipase plcgamma1 progenitors publication recapitulated sca1 stat5a tightly
Tagcloud (Intersection) ?