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TIRAP and CCDC47
Number of citations of the paper that reports this interaction (PMID
21903422
)
33
Data Source:
BioGRID
(pull down)
TIRAP
CCDC47
Gene Name
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
coiled-coil domain containing 47
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Endocytic Vesicle
Ruffle Membrane
Intercellular Bridge
Endoplasmic Reticulum
Membrane
Integral Component Of Membrane
Molecular Function
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein Binding, Bridging
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Calcium Ion Binding
Protein Binding
Poly(A) RNA Binding
Biological Process
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Growth Of Symbiont In Host
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of Interleukin-6 Biosynthetic Process
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Protein Homodimerization Activity
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Osteoblast Differentiation
ER Overload Response
Post-embryonic Development
Calcium Ion Homeostasis
Pathways
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
25 interactors:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK1
IRAK2
IRAK4
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
7 interactors:
IRAK1
IRF7
RPL7A
SARM1
TIRAP
TMEM173
TOM1L1
Entrez ID
114609
57003
HPRD ID
05878
17041
Ensembl ID
ENSG00000150455
ENSG00000108588
Uniprot IDs
P58753
Q96A33
PDB IDs
2Y92
3UB2
3UB3
3UB4
4FZ5
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Regulation Of Innate Immune Response
Immune Response
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Response To Biotic Stimulus
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Defense Response
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Response To Other Organism
Positive Regulation Of Innate Immune Response
Immune System Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Chemokine Production
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Immune Response
Response To Organic Substance
Cellular Response To Organic Substance
Regulation Of Chemokine Production
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Immune System Process
Response To Stress
Immune Response-regulating Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Stimulus
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Molecule Of Bacterial Origin
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Regulation Of Intracellular Signal Transduction
Response To Lipopolysaccharide
Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Immune System Process
Response To External Stimulus
Cell Communication
Response To Molecule Of Bacterial Origin
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Cytokine Production
Positive Regulation Of Interleukin-6 Production
MyD88-independent Toll-like Receptor Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Interferon-beta Production
Positive Regulation Of Immune Response
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Type I Interferon Production
Immune Response-regulating Signaling Pathway
Type I Interferon Production
Immune Response
Regulation Of Immune System Process
Defense Response
Response To Other Organism
Response To Biotic Stimulus
Regulation Of Toll-like Receptor Signaling Pathway
Regulation Of Interferon-beta Production
Immune System Process
Positive Regulation Of Cytokine Production
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Binding
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Cellular Response To Cytokine Stimulus
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Binding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
MDA-5 Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Cytokine Production
Tagcloud
?
7kch
arpe19
atherosclerosis
autooxidation
chamber
cholesterol
deposits
efflux
esters
eye
implants
inductions
inserted
instead
involve
ketocholesterol
lipoprotein
macular
myd88
oxidized
robust
rsks
seem
seems
suspected
tlr4
tram
trif
upr
Tagcloud (Difference)
?
7kch
arpe19
atherosclerosis
autooxidation
chamber
cholesterol
deposits
efflux
esters
eye
implants
inductions
inserted
instead
involve
ketocholesterol
lipoprotein
macular
myd88
oxidized
robust
rsks
seem
seems
suspected
tlr4
tram
trif
upr
Tagcloud (Intersection)
?