CD247 and CD5

Number of citations of the paper that reports this interaction (PubMedID 1385158)
0

Data Source:
HPRD (in vitro, in vivo)

		CD247	CD5
Description		CD247 molecule	CD5 molecule
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway
Pathways
Drugs		Muromonab Teclistamab Odronextamab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147)	Coffee consumption ( 31046077) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088 24076602) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	21 interacting genes: CAMK2D CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CSNK2A1 DYNLT3 FYN HNRNPU LCK PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70
Entrez ID		919	921
HPRD ID		01729	01078
Ensembl ID		ENSG00000198821	ENSG00000110448
Uniprot IDs		A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0	P06127
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4	2JA4 2JOP 2JP0 2OTT
Enriched GO Terms of Interacting Partners?		Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex	Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Plasma Membrane Leukocyte Activation Signal Transduction Positive Regulation Of Immune System Process Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation Adaptive Immune Response Regulation Of Immune System Process T Cell Receptor Complex B Cell Receptor Signaling Pathway Cell-cell Junction Immune Response-activating Signaling Pathway Immune Response Regulation Of Immune Response Signaling Receptor Binding Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Regulation Of Apoptotic Process Protein Kinase Activity Identical Protein Binding T Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Intracellular Signal Transduction Membrane Raft Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Lymphocyte Differentiation Phosphatidylinositol 3-kinase Binding Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of T Cell Activation Kinase Activity Regulation Of Hemopoiesis Negative Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Cell-cell Adhesion
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