TIRAP and TRAM1

Number of citations of the paper that reports this interaction (PubMedID 12721283)
0

Data Source:
HPRD (in vivo)

		TIRAP	TRAM1
Description		TIR domain containing adaptor protein	translocation associated membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane Endocytic Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Response To Unfolded Protein Protein Transport Protein Insertion Into ER Membrane
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)	SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Neutrophil percentage of granulocytes ( 27863252)	Cardiac Troponin-T levels ( 23247143) Erythrocyte cadmium concentration in never smokers ( 27005419) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		25 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1	12 interacting genes: APP CREB3 DRD2 ESR1 ESR2 GUCA2A SEC61B TICAM1 TIRAP TRAF6 UBC VKORC1
Entrez ID		114609	23471
HPRD ID		05878	05545
Ensembl ID		ENSG00000150455	ENSG00000067167
Uniprot IDs		P58753	G3XAN4 Q15629 Q6FHL3
PDB IDs		2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB 8JZM
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Chemokine Production Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Chemokine Production Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Defense Response Innate Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Immune Response Defense Response To Symbiont Defense Response To Virus Defense Response To Other Organism Interleukin-33-mediated Signaling Pathway Immune System Process Interleukin-1-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Immune System Process Response To External Biotic Stimulus Response To Stress Regulation Of Type I Interferon Production Positive Regulation Of Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-6 Production Response To Virus MyD88-independent Toll-like Receptor Signaling Pathway	Positive Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Metabolic Process Nuclear Estrogen Receptor Activity Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipid Response To Lipid Regulation Of Defense Response Positive Regulation Of Chemokine Production Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokine Production Signaling Adaptor Activity Estrogen Response Element Binding TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Leukocyte Chemotaxis MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of JNK Cascade Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neurotransmitter Uptake Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Nuclear Steroid Receptor Activity Intracellular Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation
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