TIRAP

Description		TIR domain containing adaptor protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane Endocytic Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Neutrophil percentage of granulocytes ( 27863252)
Interacting Genes		25 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1
Entrez ID		114609
HPRD ID		05878
Ensembl ID		ENSG00000150455
Uniprot IDs		P58753
PDB IDs		2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB 8JZM
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Chemokine Production Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Chemokine Production Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Defense Response Innate Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Immune Response Defense Response To Symbiont Defense Response To Virus Defense Response To Other Organism Interleukin-33-mediated Signaling Pathway Immune System Process Interleukin-1-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Immune System Process Response To External Biotic Stimulus Response To Stress Regulation Of Type I Interferon Production Positive Regulation Of Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-6 Production Response To Virus MyD88-independent Toll-like Receptor Signaling Pathway
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