CD247 and TFRC

Number of citations of the paper that reports this interaction (PMID 9448136)
0

Data Source:
HPRD (in vitro, in vivo)

		CD247	TFRC
Gene Name		CD247 molecule	transferrin receptor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Extracellular Region Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Membrane-bounded Vesicle Vesicle Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway	Regulation Of Cell Growth Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Viral Process Osteoclast Differentiation Transferrin Transport Cellular Response To Drug Regulation Of Cell Proliferation Positive Regulation Of Bone Resorption Transmembrane Transport Iron Ion Import
Pathways			Iron uptake and transport Golgi Associated Vesicle Biogenesis Transferrin endocytosis and recycling trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)	Mean corpuscular hemoglobin ( 20139978 19862010) Mean corpuscular volume ( 20139978 19862010) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517)
Protein-Protein Interactions		38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	11 interactors: ACAP1 B4GALT1 CD247 CD4 GABARAP HFE RAB5B RAB8A RANBP9 SGTA TF
Entrez ID		919	7037
HPRD ID		01729	01812
Ensembl ID		ENSG00000198821	ENSG00000072274
Uniprot IDs		P20963	A8K6Q8 P02786
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation	Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Cellular Protein Localization Cellular Localization Transport Rab Protein Signal Transduction Cellular Response To Iron Ion Starvation Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation T Cell Costimulation Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Iron Ion Transport Regulation Of Defense Response To Virus Cellular Iron Ion Homeostasis T Cell Receptor Signaling Pathway Establishment Of Localization In Cell Iron Ion Homeostasis Lactose Biosynthetic Process Golgi Vesicle Fusion To Target Membrane Membrane Fusion Viral Process Immune System Process Response To Stimulus Antigen Receptor-mediated Signaling Pathway Cellular Response To Starvation Transition Metal Ion Homeostasis Response To Stress Regulation Of Exocytosis Disaccharide Metabolic Process Positive Regulation Of Immune Response Cellular Response To Nutrient Levels Response To Starvation Iron Ion Import Into Cell Vesicle-mediated Transport Penetration Of Zona Pellucida Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Plasma Membrane To Endosome Transport Intracellular Transport Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of T Cell Activation Cellular Response To Extracellular Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Ras Protein Signal Transduction Multicellular Organismal Homeostasis Regulation Of Acrosome Reaction Positive Regulation Of Cell-cell Adhesion Cell Communication
Tagcloud ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman top2a tubb3 tyms vegfr2
Tagcloud (Difference) ?		already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project quantification seq spatially supported t1d tcr throughput utilized wealth	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized ranking rectal reference represented rplpo rrm1 separately stmn1 taqman top2a tubb3 tyms vegfr2
Tagcloud (Intersection) ?		qrt