CD247 and TFRC

Number of citations of the paper that reports this interaction (PubMedID 9448136)
0

Data Source:
HPRD (in vitro, in vivo)

		CD247	TFRC
Description		CD247 molecule	transferrin receptor
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex	Extracellular Region Extracellular Space Endosome Early Endosome Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Blood Microparticle Postsynapse Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse Extracellular Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein-folding Chaperone Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Regulation Of Cell Growth Response To Hypoxia Iron Ion Transport Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Nutrient Response To Iron Ion Response To Manganese Ion Positive Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Response To Retinoic Acid Transferrin Transport Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Isotype Switching Response To Copper Ion Symbiont Entry Into Host Cell Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Xenobiotic Stimulus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Transport Across Blood-brain Barrier Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor
Pathways			Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Transferrin endocytosis and recycling RND2 GTPase cycle RND1 GTPase cycle Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Muromonab Teclistamab Odronextamab	Iron Ferrous sulfate anhydrous Ferric cation Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Tetraferric tricitrate decahydrate Ferric derisomaltose
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147)	Asthma ( 31959851 30929738) Asthma (adult onset) ( 30929738) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340 33536631) Mean corpuscular hemoglobin ( 19862010 20139978 32888494 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 19862010 20139978 28453575 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 32499647)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	35 interacting genes: ACAP1 AQP6 ARL13B ASGR2 B4GALT1 C1orf159 CD247 CD4 CREB3L1 FAM209A FAM210B GABARAP GET1 GPR152 GRM2 HFE HIBADH LHFPL5 LMNA MFF MGST3 PAGE1 PINX1 RAB5B RAB8A RANBP9 RASSF3 RELL2 RMDN3 SGTA SLC10A1 SLC18A1 SNCA TF TINF2
Entrez ID		919	7037
HPRD ID		01729	01812
Ensembl ID		ENSG00000198821	ENSG00000072274
Uniprot IDs		A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0	A0A8V8TM46 A8K6Q8 B7Z2I6 G3V0E5 P02786
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I 6OKD 6W3H 6WRV 6WRW 6WRX 6Y76 7ZQS 8P0Z
Enriched GO Terms of Interacting Partners?		Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex	Membrane Protein Tyrosine Kinase Binding Beta-tubulin Binding Response To Iron Ion Mitochondrial Outer Membrane HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Catecholamine Uptake Dopamine Uptake Protein Localization To Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Basal Part Of Cell Tail-anchored Membrane Protein Insertion Into ER Membrane T Cell Receptor Complex Regulation Of Glutamate Secretion Establishment Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Protein Targeting Neurotransmitter Reuptake Dopamine Transport Ferrous Iron Binding Negative Regulation Of Telomere Maintenance Via Telomerase Cytoplasmic Vesicle Nitrate Transmembrane Transporter Activity Plasma Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Circulating Fibrinogen Levels Secretory Granule Membrane Regulation Of Dopamine Secretion Multicellular Organismal-level Iron Ion Homeostasis Negative Regulation Of Protein Catabolic Process Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Telomere Maintenance Non-motile Cilium Regulation Of Long-term Neuronal Synaptic Plasticity Protein Insertion Into ER Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Proteasomal Protein Catabolic Process Monoamine Transport Neurotransmitter Uptake Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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