NEURL1 and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		NEURL1	UBE2H
Description		neuralized E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 H
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Glutamatergic Synapse	Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Translation Regulator Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Translation Protein Monoubiquitination Notch Signaling Pathway Sperm Axoneme Assembly Nervous System Development Skeletal Muscle Tissue Development Lactation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Communication Protein Ubiquitination Regulation Of Signaling Flagellated Sperm Motility Positive Regulation Of Apoptotic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Cellular Response To Amino Acid Stimulus Positive Regulation Of Synapse Maturation Regulation Of Postsynapse Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 30061737) Early onset atrial fibrillation ( 28460022) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29617998) Prevalent atrial fibrillation ( 28416818) Response to antidepressants (symptom improvement) ( 29160301)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: UBE2D1 UBE2H UBE2N	71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		9148	7328
HPRD ID		04815	03052
Ensembl ID		ENSG00000107954	ENSG00000186591
Uniprot IDs		B4DS86 O76050	A0A3B3IU20 A4D1L5 P62256
PDB IDs			2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Regulation Of Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Post-translational Protein Modification Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Regulation Of TOR Signaling Proteolysis Regulation Of Protein Ubiquitination ATP Binding UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Ubiquitin Conjugating Enzyme Complex Protein Modification Process Nucleotide Binding Transferase Activity Positive Regulation Of Protein Modification Process Catabolic Process Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Response To Nutrient Levels Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Modification Process DNA Double-strand Break Processing Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Postreplication Repair Positive Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination Protein Monoubiquitination Negative Regulation Of BMP Signaling Pathway	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism
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