LOXL2 and DAPK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LOXL2	DAPK1
Description		lysyl oxidase like 2	death associated protein kinase 1
Image
GO Annotations	Cellular Component	Chromatin Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleoplasm Chromosome Endoplasmic Reticulum Membrane Extracellular Matrix	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Postsynaptic Density Actin Cytoskeleton Organelle Glutamatergic Synapse DAPK1-calmodulin Complex
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Metal Ion Binding Oligosaccharide Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Syntaxin-1 Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Epithelial To Mesenchymal Transition Endothelial Cell Proliferation Sprouting Angiogenesis Chromatin Organization Positive Regulation Of Epithelial To Mesenchymal Transition Peptidyl-lysine Oxidation Collagen Fibril Organization Positive Regulation Of Chondrocyte Differentiation Protein Modification Process Endothelial Cell Migration Negative Regulation Of DNA-templated Transcription Response To Copper Ion Heterochromatin Organization Negative Regulation Of Stem Cell Population Maintenance	Defense Response To Tumor Cell Regulation Of Response To Tumor Cell Regulation Of Translation Protein Phosphorylation Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Translation Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Autophosphorylation Cellular Response To Type II Interferon Cellular Response To Hydroperoxide Apoptotic Signaling Pathway Positive Regulation Of Autophagic Cell Death Regulation Of NMDA Receptor Activity
Pathways		Elastic fibre formation Crosslinking of collagen fibrils	Caspase activation via Dependence Receptors in the absence of ligand
Drugs			5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE Fostamatinib
Diseases			Bladder cancer
GWAS		Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 20732625) Central corneal thickness ( 29760442) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood pressure ( 24954895) Cognitive function ( 24684796) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Night sleep phenotypes ( 27126917) Ovarian cancer ( 30557369) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to gemcitabine in pancreatic cancer ( 22293537)
Interacting Genes		3 interacting genes: DAPK1 HSP90AA1 LATS1	109 interacting genes: ABL1 ABLIM1 AHDC1 APEX2 ARRDC1 ARRDC1-AS1 ATF6 BAG2 BAIAP2 C11orf65 CALM1 CAPRIN1 CBLB CCDC149 CDC42EP3 CDC42SE1 CMTM4 CNTROB DENND1C DTWD1 DUS1L DUX3 EIF4ENIF1 EPHA1 FADD FAM107A FBXL14 FBXW11 FIBP GASK1B GTF2F1 HYCC2 IKBKG JHY LIMA1 LIMS1 LINC02875 LMF2 LNX1 LOXL2 MAPK1 MAPK3 MCM10 MDM2 MIB1 MRGBP MTHFD2 MYL12B NCBP3 NECAB1 NECAP1 NR3C1 ORMDL2 PAK6 PAPSS2 PCP4 PHKG2 PIM1 PIM2 POLR2M PPP1R14A PPP2R1A PPP2R2D PPP2R5A PRKAG2 PRR16 PRRC2B PWP1 RAPGEF3 RASGRP2 RCHY1 RFC5 RHBDD1 RPAP3 RPL41 SARNP SCEL SCRN3 SCYL1 SGK2 SH2D2A SLAIN2 SNRPA SNURF SNX9 SPATS2 SPRR2G SRSF10 STARD3 STUB1 STX1A TAS2R60 TBC1D22B TNFRSF1A TPD52L1 TRADD TRAPPC2 TTC27 TUBB4B UNC5A UNC5B UNC5C VGLL4 VN1R1 WWTR1 YWHAB ZAP70 ZMAT4 ZMYM5
Entrez ID		4017	1612
HPRD ID		09446	02902
Ensembl ID		ENSG00000134013	ENSG00000196730
Uniprot IDs		Q9Y4K0	B4DHI4 P53355 Q59H88
PDB IDs		5ZE3	1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L 4PF4 4TL0 4TXC 4UV0 4YO4 4YPD 5AUT 5AUU 5AUV 5AUW 5AUX 5AUY 5AUZ 5AV0 5AV1 5AV2 5AV3 5AV4 6AAR 6FHA 6FHB 6GY5 6IN4 6QMO 6QN4 7CCU 7CCV 7CCW 8IE5 8IE6 8IE7 8IE8 8ODZ 8OE0 8OE4 8PB1 9DUB 9DUE 9INV 9INW 9INX 9MIU
Enriched GO Terms of Interacting Partners?		ATP Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of NMDA Receptor Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Component Size Rho GDP-dissociation Inhibitor Binding CTP Binding DATP Binding Positive Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Regulation Of Protein Localization To Nucleus Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Sperm Mitochondrial Sheath Nucleotide Binding Phosphorylation Cellular Response To Hydroperoxide Protein Serine Kinase Activity Protein Phosphorylation GTP Binding Protein Serine/threonine Kinase Activity Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Chromosome Organization Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Defense Response To Tumor Cell Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cell Size Protein Unfolding Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Kinase Activity Positive Regulation Of Apoptotic Process Protein Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Positive Regulation Of Catabolic Process Glutamatergic Synapse	Cytosol Netrin Receptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Cytoskeleton Organization Bergmann Glial Cell Differentiation Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Astrocyte Differentiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-34-mediated Signaling Pathway Regulation Of Protein Stability Protein Phosphatase Type 2A Complex Apoptotic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Golgi Inheritance Tumor Necrosis Factor Receptor Superfamily Complex Thymus Development Programmed Cell Death Cell Death Cytoplasm Positive Regulation Of Organelle Organization Protein Kinase Activity Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation ERBB2 Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Kinase Binding Endocytosis Regulation Of Cytoskeleton Organization Receptor Serine/threonine Kinase Binding Protein Domain Specific Binding Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Filament Bundle Assembly T Cell Receptor Signaling Pathway Lymphocyte Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Death-inducing Signaling Complex
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