LOXL2

Description		lysyl oxidase like 2
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GO Annotations	Cellular Component	Chromatin Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleoplasm Chromosome Endoplasmic Reticulum Membrane Extracellular Matrix
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Metal Ion Binding Oligosaccharide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Epithelial To Mesenchymal Transition Endothelial Cell Proliferation Sprouting Angiogenesis Chromatin Organization Positive Regulation Of Epithelial To Mesenchymal Transition Peptidyl-lysine Oxidation Collagen Fibril Organization Positive Regulation Of Chondrocyte Differentiation Protein Modification Process Endothelial Cell Migration Negative Regulation Of DNA-templated Transcription Response To Copper Ion Heterochromatin Organization Negative Regulation Of Stem Cell Population Maintenance
Pathways		Elastic fibre formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 20732625) Central corneal thickness ( 29760442) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: DAPK1 HSP90AA1 LATS1
Entrez ID		4017
HPRD ID		09446
Ensembl ID		ENSG00000134013
Uniprot IDs		Q9Y4K0
PDB IDs		5ZE3
Enriched GO Terms of Interacting Partners?		ATP Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of NMDA Receptor Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Component Size Rho GDP-dissociation Inhibitor Binding CTP Binding DATP Binding Positive Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Regulation Of Protein Localization To Nucleus Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Sperm Mitochondrial Sheath Nucleotide Binding Phosphorylation Cellular Response To Hydroperoxide Protein Serine Kinase Activity Protein Phosphorylation GTP Binding Protein Serine/threonine Kinase Activity Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Chromosome Organization Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Defense Response To Tumor Cell Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cell Size Protein Unfolding Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Kinase Activity Positive Regulation Of Apoptotic Process Protein Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Positive Regulation Of Catabolic Process Glutamatergic Synapse
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