DNAJB6 and EPHB4

Data Source: HiPPIP (Novel)

		DNAJB6	EPHB4
Name		DnaJ heat shock protein family (Hsp40) member B6	EPH receptor B4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway
Pathways		Regulation of HSF1-mediated heat shock response	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		None	Dasatinib N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Tesevatinib Fostamatinib
GWAS		Body mass index ( 28552196 ) Retinal detachment or retinal break ( 31816047 ) Waist circumference ( 28552196 )	Bipolar disorder ( 31043756 ) Blond vs. brown/black hair color ( 30531825 ) Mean corpuscular hemoglobin ( 27863252 ) Mean corpuscular volume ( 27863252 ) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020 ) Platelet distribution width ( 32888494 ) Resting heart rate ( 27798624 ) Takayasu arteritis ( 33308445 )
Novel Interactors		1 novel interactors: EPHB4	4 novel interactors: CLDN3 DNAJB6 EMILIN1 MAP3K4
Interacting Genes		22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	7 interacting genes: APP DTX3 EFNB2 FBXO7 GRIN1 SDC3 VCP
Entrez ID		10049	2050
HPRD ID		07107	02481
Ensembl ID		ENSG00000105993	ENSG00000196411
Uniprot IDs		A0A0J9YX62 E9PH18 O75190	P54760 Q541P7 Q96L35
PDB IDs		6U3R 6U3S 7JSQ 7QBY	2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 6FNI 6FNJ 6FNK 6FNL 6FNM
GO Terms Enriched among Interactors		Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm	Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Glutamate Receptor Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Synaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Response To Light Stimulus Regulation Of Cell Activation Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Biological Quality Amylin Binding Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Metabolic Process Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Response To Amyloid-beta Cell Adhesion Protein-containing Complex Lipoprotein Particle Extracellular Matrix Organization Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Extracellular Structure Organization Identical Protein Binding Negative Regulation Of Phosphate Transmembrane Transport Positive Regulation Of Wound Healing Establishment Of Endothelial Blood-brain Barrier Positive Regulation Of Aorta Morphogenesis Response To Glycine Propylene Metabolic Process Male Germ-line Sex Determination Flavin Adenine Dinucleotide Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination EMILIN Complex