DNAJB6 and SKAP2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		DNAJB6	SKAP2
Description		DnaJ heat shock protein family (Hsp40) member B6	src kinase associated phosphoprotein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	Protein Binding
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation
Pathways		Regulation of HSF1-mediated heat shock response	Signal regulatory protein family interactions
Drugs
Diseases
GWAS		Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Hip index ( 34021172) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)
Interacting Genes		22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	20 interacting genes: APP BLK DNAJB6 EEIG1 FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
Entrez ID		10049	8935
HPRD ID		07107	05558
Ensembl ID		ENSG00000105993	ENSG00000005020
Uniprot IDs		A0A0J9YX62 E9PH18 O75190	B7Z5R3 O75563
PDB IDs		6U3R 6U3S 7JSQ 7QBY	3OMH
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm	Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Immune System Process Protein Phosphorylation Regulation Of Immune Response Phosphorylation Membrane Raft Protein Autophosphorylation Signaling Receptor Activator Activity Antigen Receptor-mediated Signaling Pathway Integrin-mediated Signaling Pathway Signal Transduction T Cell Costimulation Phosphotyrosine Residue Binding Negative Regulation Of Immune Response Ephrin Receptor Signaling Pathway ATP Binding Immune Effector Process Positive Regulation Of Intracellular Signal Transduction Cellular Developmental Process Negative Regulation Of Defense Response Regulation Of Transport Ephrin Receptor Binding Negative Regulation Of Inflammatory Response Nucleotide Binding Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process
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