DNAJB6 and MYOM1

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		DNAJB6	MYOM1
Name		DnaJ heat shock protein family (Hsp40) member B6	myomesin 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Cytoplasm Striated Muscle Myosin Thick Filament Sarcomere M Band Myosin Filament
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Muscle Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Extraocular Skeletal Muscle Development Positive Regulation Of Gene Expression Protein Kinase A Signaling Sarcomere Organization Positive Regulation Of Protein Secretion
Pathways		Regulation of HSF1-mediated heat shock response	None
GWAS		Body mass index ( 28552196 ) Retinal detachment or retinal break ( 31816047 ) Waist circumference ( 28552196 )	Brain volume in infants (white matter) ( 28763065 ) Night sleep phenotypes ( 27126917 ) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737 )
Novel Interactors		1 novel interactors: EPHB4	None recorded
Interacting Genes		22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	16 interacting genes: ANKRD28 C1QTNF9 CLK1 DNAJB6 DYSF KRT31 KRTAP1-1 KRTAP5-7 MTUS2 MYH9 PDE4DIP PPP1R16A SYNE1 TFIP11 TRIM23 TTN
Entrez ID		10049	8736
HPRD ID		07107	04618
Ensembl ID		ENSG00000105993	ENSG00000101605
Uniprot IDs		A0A0J9YX62 E9PH18 O75190	P52179
PDB IDs		6U3R 6U3S 7JSQ 7QBY	2R15 2Y23 2Y25 3RBS 5FM4 5FM5 5FM8 6T3O 6ZVA
GO Terms Enriched among Interactors		Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm	None