DNAJB6 and PGM1

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		DNAJB6	PGM1
Name		DnaJ heat shock protein family (Hsp40) member B6	phosphoglucomutase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	Magnesium Ion Binding Phosphoglucomutase Activity Protein Binding Isomerase Activity Intramolecular Phosphotransferase Activity Metal Ion Binding
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway
Pathways		Regulation of HSF1-mediated heat shock response	Glycogen synthesis Defective PGM1 causes PGM1-CDG Neutrophil degranulation Glycogen breakdown (glycogenolysis) Galactose catabolism
Drugs		None	Alpha-D-Glucose 1,6-Bisphosphate Alpha-D-Glucose-1-Phosphate-6-Vanadate
GWAS		Body mass index ( 28552196 ) Retinal detachment or retinal break ( 31816047 ) Waist circumference ( 28552196 )	Alcohol consumption (transferrin glycosylation) ( 21665994 ) Type 1 diabetes ( 19430480 32005708 33830302 34012112 34127860 ) Type 2 diabetes ( 32499647 )
Novel Interactors		1 novel interactors: EPHB4	2 novel interactors: CHAF1B XRN2
Interacting Genes		22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	19 interacting genes: APP DNAJB6 DYRK3 ENO3 HSPB2 KIF1B LINC01554 NLRP3 OGT PAXIP1 PEA15 POT1 S100A1 S100B TERF1 TERF2IP TINF2 TMEM132D USP4
Entrez ID		10049	5236
HPRD ID		07107	01389
Ensembl ID		ENSG00000105993	ENSG00000079739
Uniprot IDs		A0A0J9YX62 E9PH18 O75190	B4DDQ8 B7Z6C2 P36871
PDB IDs		6U3R 6U3S 7JSQ 7QBY	5EPC 5F9C 5HSH 5JN5 5TR2 5VBI 5VEC 5VG7 5VIN 6SNO 6SNP 6SNQ 6UIQ 6UO6 7S0W 7S77
GO Terms Enriched among Interactors		Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chorion Development Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Assembly Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric D-loop Disassembly Chromosome, Telomeric Region Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region RAGE Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process S100 Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process DNA Metabolic Process Regulation Of Chromosome Organization Regulation Of TORC1 Signaling Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Unfolded Protein Binding Regulation Of Cellular Response To Stress Identical Protein Binding Chromosome Organization