DNAJB6 and MLF1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		DNAJB6	MLF1
Name		DnaJ heat shock protein family (Hsp40) member B6	myeloid leukemia factor 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytoskeleton Cilium Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	DNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Myeloid Progenitor Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Regulation of HSF1-mediated heat shock response	None
GWAS		Body mass index ( 28552196 ) Retinal detachment or retinal break ( 31816047 ) Waist circumference ( 28552196 )	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Depression ( 29700475 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Major depressive disorder ( 27479909 ) PR interval ( 32439900 ) Sporadic neuroblastoma ( 28545128 ) Systolic blood pressure ( 30224653 )
Novel Interactors		1 novel interactors: EPHB4	5 novel interactors: CLRN1 GBA1 GMPS RARRES1 RNF13
Interacting Genes		22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	9 interacting genes: CENPU COP1 COPS3 DNAJB6 GRIK5 MAGEA11 MEOX2 NRBP1 YWHAZ
Entrez ID		10049	4291
HPRD ID		07107	03239
Ensembl ID		ENSG00000105993	ENSG00000178053
Uniprot IDs		A0A0J9YX62 E9PH18 O75190	A0A0S2Z4A4 A0A0S2Z4U8 A0A140VKD2 A0A494C175 A0A499FJ64 B2RD48 C9JNE5 C9K0D4 P58340 Q2TLE4
PDB IDs		6U3R 6U3S 7JSQ 7QBY	3UAL 3UBW 6Y8E
GO Terms Enriched among Interactors		Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm	None