DNAJB6 and POLR1D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DNAJB6	POLR1D
Description		DnaJ heat shock protein family (Hsp40) member B6	RNA polymerase I and III subunit D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol Nuclear DNA-directed RNA Polymerase Complex
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase III
Pathways		Regulation of HSF1-mediated heat shock response	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)	Body mass index ( 26426971)
Interacting Genes		22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	15 interacting genes: CDC25A CEBPA CRKL DDIT3 DNAJB4 DNAJB6 E2F4 GRB2 HAX1 MAGEA11 MRPL12 NFKBIB NR3C1 POLR1C PXN
Entrez ID		10049	51082
HPRD ID		07107	17877
Ensembl ID		ENSG00000105993	ENSG00000186184
Uniprot IDs		A0A0J9YX62 E9PH18 O75190	A0A087WTY1 P0DPB5 P0DPB6
PDB IDs		6U3R 6U3S 7JSQ 7QBY	7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm	CHOP-C/EBP Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Protein Domain Specific Binding Regulation Of RNA Biosynthetic Process Protein-folding Chaperone Binding Transcription By RNA Polymerase I Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression ATPase Activator Activity Nucleoplasm Cytoplasm Regulation Of Primary Metabolic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cortex Integrated Stress Response Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Dexamethasone Macrophage Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Phosphotyrosine Residue Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Guanyl-nucleotide Exchange Factor Adaptor Activity Nuclear Glucocorticoid Receptor Activity Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Xenobiotic Stimulus Gland Development Negative Regulation Of Biosynthetic Process Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis
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