DNAJB6 and MRTO4

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		DNAJB6	MRTO4
Description		DnaJ heat shock protein family (Hsp40) member B6	MRT4 homolog, ribosome maturation factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Preribosome, Large Subunit Precursor
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	RNA Binding Protein Binding
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process RRNA Processing Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321)
Interacting Genes		22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	4 interacting genes: CEBPA DNAJB6 ISG15 TERF2IP
Entrez ID		10049	51154
HPRD ID		07107	12725
Ensembl ID		ENSG00000105993	ENSG00000053372
Uniprot IDs		A0A0J9YX62 E9PH18 O75190	Q9UKD2
PDB IDs		6U3R 6U3S 7JSQ 7QBY	8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm	CHOP-C/EBP Complex Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Protein Localization To Organelle Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of DNA Recombination At Telomere White Fat Cell Proliferation Positive Regulation Of Protein Oligomerization Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex ISG15-protein Conjugation Shelterin Complex Response To Phenylpropanoid Chorio-allantoic Fusion Protection From Non-homologous End Joining At Telomere Negative Regulation Of Nucleobase-containing Compound Metabolic Process Urea Metabolic Process Nucleoplasm HMG Box Domain Binding Urea Cycle STAT Family Protein Binding Regulation Of Protein Metabolic Process Fat Cell Proliferation Response To Type I Interferon Negative Regulation Of Inclusion Body Assembly Protein Localization To Chromosome, Telomeric Region Nuclear Telomere Cap Complex Telomere Capping G-rich Strand Telomeric DNA Binding Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Regulation Of Hemopoiesis Osteoblast Development Intracellular Protein Localization Protein Tag Activity Regulation Of Cellular Response To Heat Telomere Maintenance In Response To DNA Damage Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Response To Peptide
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