MX2 and ATRIP

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		MX2	ATRIP
Name		MX dynamin like GTPase 2	ATR interacting protein
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Cytosol Microtubule Plasma Membrane Synapse Presynapse	Nucleus Nucleoplasm ATR-ATRIP Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Immune System Process Defense Response Response To Virus Protein Transport Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Interferon-alpha Innate Immune Response Regulation Of Nucleocytoplasmic Transport MRNA Transport Defense Response To Virus Regulation Of Cell Cycle	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Regulation Of Double-strand Break Repair
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
GWAS		Cutaneous malignant melanoma ( 32341527 ) Melanoma ( 21983787 28212542 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Parkinson disease and lewy body pathology ( 25663231 ) Tau burden ( 33426524 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 )
Novel Interactors		6 novel interactors: IGFBP4 LSS MX1 NDUFV3 PKNOX1 STK38L	None recorded
Interacting Genes		3 interacting genes: ATRIP EHMT2 PIAS2	28 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP ETAA1 FAAP100 FAM156A LNX1 MCM2 MCM3 MCM5 MCM6 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SIRT2 SPRY2 TASOR2 ZBTB14
Entrez ID		4600	84126
HPRD ID		01001	Not available
Ensembl ID		ENSG00000183486	ENSG00000164053
Uniprot IDs		P20592	Q8WXE1
PDB IDs		4WHJ 4X0R 5UOT	4IGK 4NB3 5YZ0 7XV4
GO Terms Enriched among Interactors		None	DNA Metabolic Process DNA Repair DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination CMG Complex MCM Complex Recombinational Repair DNA Replication Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response Double-strand Break Repair DNA Recombination Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Single-stranded DNA Binding Regulation Of DNA Replication DNA Replication Origin Binding Cellular Response To Stress Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Replication Initiation Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Phase Transition Helicase Activity Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Nucleoplasm Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Meiotic Cell Cycle 3'-5' DNA Helicase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Exit From Mitosis Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of Phosphorylation Regulation Of DNA Damage Checkpoint Nucleolus