MX2 and LSS

Data Source: HiPPIP (Novel)

		MX2	LSS
Name		MX dynamin like GTPase 2	lanosterol synthase
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Cytosol Microtubule Plasma Membrane Synapse Presynapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding	Lanosterol Synthase Activity Protein Binding Isomerase Activity Intramolecular Transferase Activity
	Biological Process	Immune System Process Defense Response Response To Virus Protein Transport Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Interferon-alpha Innate Immune Response Regulation Of Nucleocytoplasmic Transport MRNA Transport Defense Response To Virus Regulation Of Cell Cycle	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		None	R048-8071 Lanosterol
GWAS		Cutaneous malignant melanoma ( 32341527 ) Melanoma ( 21983787 28212542 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Parkinson disease and lewy body pathology ( 25663231 ) Tau burden ( 33426524 )	Glutathione peroxidase in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) White blood cell count ( 27863252 )
Novel Interactors		6 novel interactors: IGFBP4 LSS MX1 NDUFV3 PKNOX1 STK38L	3 novel interactors: MX2 NUP214 SIRT5
Interacting Genes		3 interacting genes: ATRIP EHMT2 PIAS2	9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A
Entrez ID		4600	4047
HPRD ID		01001	02945
Ensembl ID		ENSG00000183486	ENSG00000160285
Uniprot IDs		P20592	B2R694 P48449
PDB IDs		4WHJ 4X0R 5UOT	1W6J 1W6K
GO Terms Enriched among Interactors		None	Bile Acid:sodium Symporter Activity Nitrate Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Cytoplasmic Side Of Nuclear Pore Positive Regulation Of Male Germ Cell Proliferation Peptidyl-lysine Demalonylation Protein Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein-malonyllysine Demalonylase Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Response To Ischemia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chemokine-mediated Signaling Pathway Protein-glutaryllysine Deglutarylase Activity Protein-succinyllysine Desuccinylase Activity Protein Deglutarylation Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Nuclear Pore Symporter Activity Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane MRNA Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Male Germ Cell Proliferation Histone Deacetylase Activity, NAD-dependent Monocarboxylic Acid Transport