WASL and PRPF40A

Number of citations of the paper that reports this interaction (PubMedID 14697212)
0

Data Source:
HPRD (in vitro, in vivo)

		WASL	PRPF40A
Description		WASP like actin nucleation promoting factor	pre-mRNA processing factor 40A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Actin Cap Endocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome Glutamatergic Synapse	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome
	Molecular Function	Actin Binding Protein Binding GTPase Regulator Activity	RNA Binding Protein Binding
	Biological Process	Vesicle Budding From Membrane Actin Filament Organization Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Actin Cytoskeleton Organization Actin Filament Polymerization Vesicle Transport Along Actin Filament Protein-containing Complex Localization Regulation Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Dendritic Spine Morphogenesis Protein-containing Complex Assembly Regulation Of Postsynapse Organization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Lymphocyte Migration	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation NOSTRIN mediated eNOS trafficking Nephrin family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Platelet count ( 22139419 27863252) Plateletcrit ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		62 interacting genes: ABI2 ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 ARPC4 BIN1 CDC42 CORO7 CTTN DNMBP EGFR EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITCH ITGB1BP2 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD OSTF1 PACSIN1 PACSIN2 PACSIN3 PFN1 PRMT2 PRPF40A PSTPIP1 PTK6 RHOQ RIPPLY3 RNF8 RPL7AP66 SDCBP SH3GL3 SH3RF1 SNX9 SORBS2 SRC TNNT3 TRIP10 UBASH3A UBASH3B VASP VIPR1 WIPF1 WIPF2 WIPF3 WWP1 ZNF395	132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451
Entrez ID		8976	55660
HPRD ID		05448	10995
Ensembl ID		ENSG00000106299	ENSG00000196504
Uniprot IDs		O00401	A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400
PDB IDs		2FF3 2LNH 2VCP 4CC2 4CC7 9DLX	1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX
Enriched GO Terms of Interacting Partners?		Endocytosis Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Import Into Cell Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Cytoplasm Cytosol Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Profilin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Endocytosis Positive Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport Regulation Of Cell Projection Organization Cytoskeleton Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Size Cytoskeletal Anchor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Focal Adhesion Regulation Of Cell Projection Assembly Cytoskeleton Plasma Membrane Tubulation Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Organization Proline-rich Region Binding Arp2/3 Complex-mediated Actin Nucleation Extracellular Exosome SH3 Domain Binding Regulation Of Vesicle-mediated Transport Actin Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex
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