AP1S2 and AP1G1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (affinity chromatography technology, biochemical, cross-linking study)
HPRD (two hybrid)

		AP1S2	AP1G1
Description		adaptor related protein complex 1 subunit sigma 2	adaptor related protein complex 1 subunit gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-type Membrane Coat Adaptor Complex AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Intracellular Vesicle Presynapse
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Protein Binding Collagen Binding Kinesin Binding GTP-dependent Protein Binding Small GTPase Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Melanosome Assembly	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Synaptic Vesicle Endocytosis Platelet Dense Granule Organization Golgi To Lysosome Transport Basolateral Protein Secretion Melanosome Assembly
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Lung function (FEV1/FVC) ( 26635082)	General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Post bronchodilator FEV1 ( 26634245) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		5 interacting genes: AP1G1 AP1G2 GGA3 MAB21L2 TNS2	30 interacting genes: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CCDC91 CLINT1 CLTC DNER EPS15 GGA1 GGA2 GGA3 HEATR5B KIF13A MAP1A PLK2 PSEN2 RABEP1 RABGEF1 SNX9 SPTB SYNRG SYP UBL7 ZNF512B
Entrez ID		8905	164
HPRD ID		04636	04637
Ensembl ID		ENSG00000182287	ENSG00000166747
Uniprot IDs		A0A5F9ZHW1 A0A5F9ZI43 A6NH01 H7BZG6 P56377 Q549M9	A0A140VJE7 O43747 Q8IY97
PDB IDs			1IU1
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Clathrin Adaptor Activity Intracellular Vesicle Golgi To Vacuole Transport Vacuolar Transport AP-1 Adaptor Complex Membrane Coat Golgi Vesicle Transport Intracellular Protein Transport Lysosomal Transport Synaptic Vesicle Budding From Endosome Recycling Endosome Cytoplasmic Vesicle Membrane Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Trans-Golgi Network Positive Regulation Of Lysosomal Protein Catabolic Process Small GTPase Binding Vesicle-mediated Transport Protein Transport Endosome To Melanosome Transport Intracellular Transport Endosome Membrane Body Morphogenesis Embryonic Body Morphogenesis Positive Regulation Of Protein Catabolic Process In The Vacuole Golgi To Lysosome Transport Regulation Of Lysosomal Protein Catabolic Process Early Endosome Establishment Of Protein Localization Golgi Apparatus Protein Transporter Activity Golgi-associated Vesicle Melanosome Assembly GTP-dependent Protein Binding Cellular Localization Establishment Of Localization In Cell Peptidyl-tyrosine Dephosphorylation Platelet Dense Granule Organization Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Targeting To Lysosome Protein Localization To Cell Surface Response To Muscle Activity Intracellular Protein Localization Vesicle Budding From Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Golgi To Plasma Membrane Protein Transport	Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Clathrin-coated Vesicle AP-1 Adaptor Complex Intracellular Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Golgi Apparatus Early Endosome Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Endocytosis Endosomal Transport Golgi To Plasma Membrane Transport Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Golgi To Plasma Membrane Protein Transport Import Into Cell Cytoplasmic Vesicle Golgi Vesicle Transport Trans-Golgi Network Establishment Of Protein Localization To Plasma Membrane Basolateral Protein Secretion Clathrin-coated Pit Clathrin Binding Endosome Melanosome Organization Cytoplasmic Vesicle Membrane Pigment Granule Organization Retrograde Transport, Endosome To Golgi Cytosol Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Localization Within Membrane Melanosome Assembly Clathrin Adaptor Activity Clathrin Coat Assembly Platelet Dense Granule Organization Receptor-mediated Endocytosis Protein Localization To Membrane Vesicle Organization Membrane Coat Protein Localization To Cell Surface Protein Localization To Plasma Membrane Ubiquitin Binding Phosphatidylinositol Binding
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