AP1S2 and TNS2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		AP1S2	TNS2
Description		adaptor related protein complex 1 subunit sigma 2	tensin 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-type Membrane Coat Adaptor Complex AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Focal Adhesion Membrane Anchoring Junction
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Zinc Ion Binding Lipid Binding Hydrolase Activity Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Melanosome Assembly	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal-level Homeostasis
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Lung function (FEV1/FVC) ( 26635082)
Interacting Genes		5 interacting genes: AP1G1 AP1G2 GGA3 MAB21L2 TNS2	150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837
Entrez ID		8905	23371
HPRD ID		04636	16256
Ensembl ID		ENSG00000182287	ENSG00000111077
Uniprot IDs		A0A5F9ZHW1 A0A5F9ZI43 A6NH01 H7BZG6 P56377 Q549M9	Q63HR2
PDB IDs			2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Clathrin Adaptor Activity Intracellular Vesicle Golgi To Vacuole Transport Vacuolar Transport AP-1 Adaptor Complex Membrane Coat Golgi Vesicle Transport Intracellular Protein Transport Lysosomal Transport Synaptic Vesicle Budding From Endosome Recycling Endosome Cytoplasmic Vesicle Membrane Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Trans-Golgi Network Positive Regulation Of Lysosomal Protein Catabolic Process Small GTPase Binding Vesicle-mediated Transport Protein Transport Endosome To Melanosome Transport Intracellular Transport Endosome Membrane Body Morphogenesis Embryonic Body Morphogenesis Positive Regulation Of Protein Catabolic Process In The Vacuole Golgi To Lysosome Transport Regulation Of Lysosomal Protein Catabolic Process Early Endosome Establishment Of Protein Localization Golgi Apparatus Protein Transporter Activity Golgi-associated Vesicle Melanosome Assembly GTP-dependent Protein Binding Cellular Localization Establishment Of Localization In Cell Peptidyl-tyrosine Dephosphorylation Platelet Dense Granule Organization Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Targeting To Lysosome Protein Localization To Cell Surface Response To Muscle Activity Intracellular Protein Localization Vesicle Budding From Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Golgi To Plasma Membrane Protein Transport	Intermediate Filament Keratin Filament Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Receptor Complex Regulation Of RNA Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Nucleus Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Basal Plasma Membrane Ruffle Membrane Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process ERBB2 Signaling Pathway Cell-substrate Adhesion Salivary Gland Morphogenesis ERBB3:ERBB2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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