AP1G1 and HEATR5B

Number of citations of the paper that reports this interaction (PubMedID 15758025)
32

Data Source:
BioGRID (pull down, affinity chromatography technology)

		AP1G1	HEATR5B
Description		adaptor related protein complex 1 subunit gamma 1	HEAT repeat containing 5B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Intracellular Vesicle Presynapse	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Clathrin-coated Vesicle Endocytic Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Collagen Binding Kinesin Binding GTP-dependent Protein Binding Small GTPase Binding Clathrin Adaptor Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Synaptic Vesicle Endocytosis Platelet Dense Granule Organization Golgi To Lysosome Transport Basolateral Protein Secretion Melanosome Assembly	Endocytosis Intracellular Protein Localization Protein Transport Retrograde Transport, Endosome To Golgi
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Post bronchodilator FEV1 ( 26634245) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 28552196) QRS duration ( 30012220) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418) Urate levels ( 31578528)
Interacting Genes		30 interacting genes: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CCDC91 CLINT1 CLTC DNER EPS15 GGA1 GGA2 GGA3 HEATR5B KIF13A MAP1A PLK2 PSEN2 RABEP1 RABGEF1 SNX9 SPTB SYNRG SYP UBL7 ZNF512B	2 interacting genes: AP1G1 KDM8
Entrez ID		164	54497
HPRD ID		04637	11145
Ensembl ID		ENSG00000166747	ENSG00000008869
Uniprot IDs		A0A140VJE7 O43747 Q8IY97	Q9P2D3
PDB IDs		1IU1
Enriched GO Terms of Interacting Partners?		Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Clathrin-coated Vesicle AP-1 Adaptor Complex Intracellular Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Golgi Apparatus Early Endosome Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Endocytosis Endosomal Transport Golgi To Plasma Membrane Transport Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Golgi To Plasma Membrane Protein Transport Import Into Cell Cytoplasmic Vesicle Golgi Vesicle Transport Trans-Golgi Network Establishment Of Protein Localization To Plasma Membrane Basolateral Protein Secretion Clathrin-coated Pit Clathrin Binding Endosome Melanosome Organization Cytoplasmic Vesicle Membrane Pigment Granule Organization Retrograde Transport, Endosome To Golgi Cytosol Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Localization Within Membrane Melanosome Assembly Clathrin Adaptor Activity Clathrin Coat Assembly Platelet Dense Granule Organization Receptor-mediated Endocytosis Protein Localization To Membrane Vesicle Organization Membrane Coat Protein Localization To Cell Surface Protein Localization To Plasma Membrane Ubiquitin Binding Phosphatidylinositol Binding	Synaptic Vesicle Budding From Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Peptidyl-arginine 3-dioxygenase Activity Golgi To Lysosome Transport Endosome To Melanosome Transport AP-1 Adaptor Complex Histone H3K36 Demethylase Activity Clathrin Adaptor Activity Intracellular Vesicle Golgi To Vacuole Transport GTP-dependent Protein Binding Melanosome Assembly Platelet Dense Granule Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Vesicle Budding From Membrane Synaptic Vesicle Endocytosis Melanosome Organization Membrane Coat Pigment Granule Organization Aminopeptidase Activity Fibroblast Proliferation Presynaptic Endocytosis Kinesin Binding Positive Regulation Of Regulated Secretory Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity G2/M Transition Of Mitotic Cell Cycle Regulation Of Natural Killer Cell Mediated Immunity Cell Cycle G2/M Phase Transition Protein Destabilization Collagen Binding Secretory Granule Organization Clathrin-coated Pit Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Circadian Regulation Of Gene Expression P53 Binding Clathrin-coated Vesicle Dioxygenase Activity Positive Regulation Of Exocytosis Endopeptidase Activity Vesicle-mediated Transport In Synapse Regulation Of Leukocyte Mediated Cytotoxicity Post-Golgi Vesicle-mediated Transport
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