AP1G1 and AP1B1

Number of citations of the paper that reports this interaction (PMID 11409905)
10

Data Source:
HPRD (two hybrid)

		AP1G1	AP1B1
Gene Name		adaptor-related protein complex 1, gamma 1 subunit	adaptor-related protein complex 1, beta 1 subunit
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome	Golgi Membrane Lysosomal Membrane Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding	Transporter Activity Protein Binding Protein Transporter Activity Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Membrane Organization Golgi To Lysosome Transport	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		20 interactors: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 CLINT1 CLTC DNER KIF13A MAP1A RAB5A RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 ZNF512B	22 interactors: AMPH AP1G1 AP1M1 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CLTC CREBBP KIF13A NTRK2 PIP5K1C PRKDC SHBG SMAD2
Entrez ID		164	162
HPRD ID		04637	02541
Ensembl ID		ENSG00000166747	ENSG00000100280
Uniprot IDs		O43747 Q8IY97	Q10567
PDB IDs		1IU1	4HMY
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Localization In Cell Endocytosis Cellular Localization Regulation Of Defense Response To Virus Transport Establishment Of Vesicle Localization Intracellular Protein Transport Vesicle Localization Cellular Protein Localization Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Organelle Localization Vesicle Targeting Vesicle Organization Viral Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Vesicle Targeting, To, From Or Within Golgi Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Immune System Process Regulation Of Endocytosis Synaptic Vesicle Recycling Receptor Internalization Endosomal Transport Negative Regulation Of Kit Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Immune System Process Vesicle Targeting, Trans-Golgi To Endosome Synaptic Vesicle Membrane Organization Regulation Of Synaptic Transmission Membrane Budding Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Endosome Size Regulation Of Opioid Receptor Signaling Pathway	Post-Golgi Vesicle-mediated Transport Regulation Of Defense Response To Virus By Virus Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Cellular Localization Viral Process Regulation Of Defense Response To Virus Establishment Of Vesicle Localization Melanosome Organization Pigment Granule Organization Vesicle Localization Cell Cycle Cell Cycle Checkpoint Antigen Processing And Presentation Of Peptide Antigen Cell Cycle Process Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Establishment Of Localization In Cell Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Antigen Processing And Presentation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Cell Cycle Phase Transition Establishment Of Organelle Localization Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Cell Differentiation Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Checkpoint Negative Regulation Of Proteolysis Cellular Protein Localization Response To Gamma Radiation Negative Regulation Of Protein Processing Cellular Pigmentation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Temperature Stimulus Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Protein Processing Negative Regulation Of Proteasomal Protein Catabolic Process
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