AP1S2

Gene Name		adaptor-related protein complex 1, sigma 2 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Coated Pit AP-type Membrane Coat Adaptor Complex Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane
	Molecular Function	Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: AP1G1 AP1G2 GGA3
Entrez ID		8905
HPRD ID		04636
Ensembl ID		ENSG00000182287
Uniprot IDs		B4DSU4 B7Z3M9 P56377 Q549M9
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport Positive Regulation Of Natural Killer Cell Degranulation Establishment Of Protein Localization Intracellular Transport Golgi To Lysosome Transport Protein Localization Establishment Of Localization In Cell Golgi To Vacuole Transport Endosome To Melanosome Transport Pigment Granule Maturation Cellular Localization Cellular Pigment Accumulation Viral Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Regulated Secretory Pathway Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Natural Killer Cell Activation Regulation Of Regulated Secretory Pathway Lysosomal Transport Cellular Pigmentation Positive Regulation Of Exocytosis Developmental Pigmentation Transport Vacuolar Transport Regulation Of Defense Response To Virus Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Pigmentation Regulation Of Exocytosis Positive Regulation Of Innate Immune Response Endosomal Transport Vesicle Organization Positive Regulation Of Protein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response
Tagcloud ?		aberrantly aberration brcc3 cpxcr1 cxorf45 ddx53 dmd fam9a fhl1 gabre gjb1 hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist