AP1S2

Description		adaptor related protein complex 1 subunit sigma 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-type Membrane Coat Adaptor Complex AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Lung function (FEV1/FVC) ( 26635082)
Interacting Genes		5 interacting genes: AP1G1 AP1G2 GGA3 MAB21L2 TNS2
Entrez ID		8905
HPRD ID		04636
Ensembl ID		ENSG00000182287
Uniprot IDs		A0A5F9ZHW1 A0A5F9ZI43 A6NH01 H7BZG6 P56377 Q549M9
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Clathrin Adaptor Activity Intracellular Vesicle Golgi To Vacuole Transport Vacuolar Transport AP-1 Adaptor Complex Membrane Coat Golgi Vesicle Transport Intracellular Protein Transport Lysosomal Transport Synaptic Vesicle Budding From Endosome Recycling Endosome Cytoplasmic Vesicle Membrane Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Trans-Golgi Network Positive Regulation Of Lysosomal Protein Catabolic Process Small GTPase Binding Vesicle-mediated Transport Protein Transport Endosome To Melanosome Transport Intracellular Transport Endosome Membrane Body Morphogenesis Embryonic Body Morphogenesis Positive Regulation Of Protein Catabolic Process In The Vacuole Golgi To Lysosome Transport Regulation Of Lysosomal Protein Catabolic Process Early Endosome Establishment Of Protein Localization Golgi Apparatus Protein Transporter Activity Golgi-associated Vesicle Melanosome Assembly GTP-dependent Protein Binding Cellular Localization Establishment Of Localization In Cell Peptidyl-tyrosine Dephosphorylation Platelet Dense Granule Organization Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Targeting To Lysosome Protein Localization To Cell Surface Response To Muscle Activity Intracellular Protein Localization Vesicle Budding From Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Golgi To Plasma Membrane Protein Transport
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