AP1G1 and AP1S2

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, two hybrid, biochemical)
HPRD (two hybrid)

		AP1G1	AP1S2
Gene Name		adaptor-related protein complex 1, gamma 1 subunit	adaptor-related protein complex 1, sigma 2 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome	Golgi Membrane Lysosomal Membrane Cytosol Coated Pit AP-type Membrane Coat Adaptor Complex Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding	Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Membrane Organization Golgi To Lysosome Transport	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 CLINT1 CLTC DNER KIF13A MAP1A RAB5A RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 ZNF512B	3 interactors: AP1G1 AP1G2 GGA3
Entrez ID		164	8905
HPRD ID		04637	04636
Ensembl ID		ENSG00000166747	ENSG00000182287
Uniprot IDs		O43747 Q8IY97	B4DSU4 B7Z3M9 P56377 Q549M9
PDB IDs		1IU1
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Localization In Cell Endocytosis Cellular Localization Regulation Of Defense Response To Virus Transport Establishment Of Vesicle Localization Intracellular Protein Transport Vesicle Localization Cellular Protein Localization Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Organelle Localization Vesicle Targeting Vesicle Organization Viral Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Vesicle Targeting, To, From Or Within Golgi Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Immune System Process Regulation Of Endocytosis Synaptic Vesicle Recycling Receptor Internalization Endosomal Transport Negative Regulation Of Kit Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Immune System Process Vesicle Targeting, Trans-Golgi To Endosome Synaptic Vesicle Membrane Organization Regulation Of Synaptic Transmission Membrane Budding Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Endosome Size Regulation Of Opioid Receptor Signaling Pathway	Intracellular Protein Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport Positive Regulation Of Natural Killer Cell Degranulation Establishment Of Protein Localization Intracellular Transport Golgi To Lysosome Transport Protein Localization Establishment Of Localization In Cell Golgi To Vacuole Transport Endosome To Melanosome Transport Pigment Granule Maturation Cellular Localization Cellular Pigment Accumulation Viral Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Regulated Secretory Pathway Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Natural Killer Cell Activation Regulation Of Regulated Secretory Pathway Lysosomal Transport Cellular Pigmentation Positive Regulation Of Exocytosis Developmental Pigmentation Transport Vacuolar Transport Regulation Of Defense Response To Virus Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Pigmentation Regulation Of Exocytosis Positive Regulation Of Innate Immune Response Endosomal Transport Vesicle Organization Positive Regulation Of Protein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response
Tagcloud ?			aberrantly aberration brcc3 cpxcr1 cxorf45 ddx53 dmd fam9a fhl1 gabre gjb1 hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist
Tagcloud (Difference) ?			aberrantly aberration brcc3 cpxcr1 cxorf45 ddx53 dmd fam9a fhl1 gabre gjb1 hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist
Tagcloud (Intersection) ?