AP1S2 and GGA3

Number of citations of the paper that reports this interaction (PubMedID 12215646)
0

Data Source:
HPRD (in vitro)

		AP1S2	GGA3
Description		adaptor related protein complex 1 subunit sigma 2	golgi associated, gamma adaptin ear containing, ARF binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-type Membrane Coat Adaptor Complex AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Melanosome Assembly	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS		Lung function (FEV1/FVC) ( 26635082)
Interacting Genes		5 interacting genes: AP1G1 AP1G2 GGA3 MAB21L2 TNS2	45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497
Entrez ID		8905	23163
HPRD ID		04636	10443
Ensembl ID		ENSG00000182287	ENSG00000125447
Uniprot IDs		A0A5F9ZHW1 A0A5F9ZI43 A6NH01 H7BZG6 P56377 Q549M9	A8K6M0 B7Z456 Q9NZ52
PDB IDs			1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Clathrin Adaptor Activity Intracellular Vesicle Golgi To Vacuole Transport Vacuolar Transport AP-1 Adaptor Complex Membrane Coat Golgi Vesicle Transport Intracellular Protein Transport Lysosomal Transport Synaptic Vesicle Budding From Endosome Recycling Endosome Cytoplasmic Vesicle Membrane Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Trans-Golgi Network Positive Regulation Of Lysosomal Protein Catabolic Process Small GTPase Binding Vesicle-mediated Transport Protein Transport Endosome To Melanosome Transport Intracellular Transport Endosome Membrane Body Morphogenesis Embryonic Body Morphogenesis Positive Regulation Of Protein Catabolic Process In The Vacuole Golgi To Lysosome Transport Regulation Of Lysosomal Protein Catabolic Process Early Endosome Establishment Of Protein Localization Golgi Apparatus Protein Transporter Activity Golgi-associated Vesicle Melanosome Assembly GTP-dependent Protein Binding Cellular Localization Establishment Of Localization In Cell Peptidyl-tyrosine Dephosphorylation Platelet Dense Granule Organization Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Targeting To Lysosome Protein Localization To Cell Surface Response To Muscle Activity Intracellular Protein Localization Vesicle Budding From Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Golgi To Plasma Membrane Protein Transport	Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity
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