AP1S2 and GGA3

Number of citations of the paper that reports this interaction (PMID 12215646)
70

Data Source:
HPRD (in vitro)

		AP1S2	GGA3
Gene Name		adaptor-related protein complex 1, sigma 2 subunit	golgi-associated, gamma adaptin ear containing, ARF binding protein 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Coated Pit AP-type Membrane Coat Adaptor Complex Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane	Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex
	Molecular Function	Protein Transporter Activity	Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization	Intracellular Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AP1G1 AP1G2 GGA3	24 interactors: AFTPH AP1S2 ARF1 ARF3 BACE1 CDKN2A CLINT1 CLTC GGA1 GGA2 IGF2R M6PR PACS1 RAB5A RABEP1 RNF11 RPS27A STAB1 SYNRG TBC1D3 TSG101 UBC VPS11 VPS18
Entrez ID		8905	23163
HPRD ID		04636	10443
Ensembl ID		ENSG00000182287	ENSG00000125447
Uniprot IDs		B4DSU4 B7Z3M9 P56377 Q549M9	A8K6I6 A8K6M0 Q9NZ52
PDB IDs			1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport Positive Regulation Of Natural Killer Cell Degranulation Establishment Of Protein Localization Intracellular Transport Golgi To Lysosome Transport Protein Localization Establishment Of Localization In Cell Golgi To Vacuole Transport Endosome To Melanosome Transport Pigment Granule Maturation Cellular Localization Cellular Pigment Accumulation Viral Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Regulated Secretory Pathway Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Natural Killer Cell Activation Regulation Of Regulated Secretory Pathway Lysosomal Transport Cellular Pigmentation Positive Regulation Of Exocytosis Developmental Pigmentation Transport Vacuolar Transport Regulation Of Defense Response To Virus Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Pigmentation Regulation Of Exocytosis Positive Regulation Of Innate Immune Response Endosomal Transport Vesicle Organization Positive Regulation Of Protein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response	Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Transport Cellular Localization Intracellular Protein Transport Membrane Organization Viral Protein Processing Endocytosis Cellular Protein Localization Viral Process Virion Assembly Post-Golgi Vesicle-mediated Transport Endosomal Transport Regulation Of Defense Response To Virus By Virus Intracellular Transport Of Virus Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Antigen Processing And Presentation Receptor-mediated Endocytosis Viral Life Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Membrane Budding Regulation Of Defense Response To Virus Protein Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Ubiquitin-protein Transferase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Notch Receptor Processing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle-mediated Transport G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Receptor Internalization Negative Regulation Of Cell Cycle Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Ubiquitination
Tagcloud ?		aberrantly aberration brcc3 cpxcr1 cxorf45 ddx53 dmd fam9a fhl1 gabre gjb1 hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist	acylation adaptin adaptors anchored apart cargo catalytically dileucine doi endosome governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs
Tagcloud (Difference) ?		aberrantly aberration brcc3 cpxcr1 cxorf45 ddx53 dmd fam9a fhl1 gabre gjb1 hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist	acylation adaptin adaptors anchored apart cargo catalytically dileucine doi endosome governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs
Tagcloud (Intersection) ?