AP1G1 and AP1S1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical, affinity chromatography technology, biochemical, biochemical, cross-linking study)
HPRD (two hybrid)

		AP1G1	AP1S1
Description		adaptor related protein complex 1 subunit gamma 1	adaptor related protein complex 1 subunit sigma 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Intracellular Vesicle Presynapse	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Terminal Bouton Intracellular Membrane-bounded Organelle Presynapse
	Molecular Function	Protein Binding Collagen Binding Kinesin Binding GTP-dependent Protein Binding Small GTPase Binding Clathrin Adaptor Activity	Protein Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Synaptic Vesicle Endocytosis Platelet Dense Granule Organization Golgi To Lysosome Transport Basolateral Protein Secretion Melanosome Assembly	Intracellular Protein Transport Receptor-mediated Endocytosis Response To Virus Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Post bronchodilator FEV1 ( 26634245) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)	Adult body size ( 32376654) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		30 interacting genes: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CCDC91 CLINT1 CLTC DNER EPS15 GGA1 GGA2 GGA3 HEATR5B KIF13A MAP1A PLK2 PSEN2 RABEP1 RABGEF1 SNX9 SPTB SYNRG SYP UBL7 ZNF512B	6 interacting genes: AP1G1 AP1G2 AP1M2 AP2A2 PICK1 RHOU
Entrez ID		164	1174
HPRD ID		04637	04635
Ensembl ID		ENSG00000166747	ENSG00000106367
Uniprot IDs		A0A140VJE7 O43747 Q8IY97	P61966
PDB IDs		1IU1	4P6Z
Enriched GO Terms of Interacting Partners?		Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Clathrin-coated Vesicle AP-1 Adaptor Complex Intracellular Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Golgi Apparatus Early Endosome Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Endocytosis Endosomal Transport Golgi To Plasma Membrane Transport Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Golgi To Plasma Membrane Protein Transport Import Into Cell Cytoplasmic Vesicle Golgi Vesicle Transport Trans-Golgi Network Establishment Of Protein Localization To Plasma Membrane Basolateral Protein Secretion Clathrin-coated Pit Clathrin Binding Endosome Melanosome Organization Cytoplasmic Vesicle Membrane Pigment Granule Organization Retrograde Transport, Endosome To Golgi Cytosol Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Localization Within Membrane Melanosome Assembly Clathrin Adaptor Activity Clathrin Coat Assembly Platelet Dense Granule Organization Receptor-mediated Endocytosis Protein Localization To Membrane Vesicle Organization Membrane Coat Protein Localization To Cell Surface Protein Localization To Plasma Membrane Ubiquitin Binding Phosphatidylinositol Binding	Clathrin Adaptor Activity AP-1 Adaptor Complex Membrane Coat Intracellular Protein Transport Basolateral Protein Secretion Clathrin Adaptor Complex Trans-Golgi Network Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Intracellular Vesicle Golgi To Vacuole Transport Cytoplasmic Vesicle Membrane Establishment Of Protein Localization Golgi Apparatus Golgi Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Presynaptic Endocytosis Cytoplasmic Vesicle Intracellular Protein Localization Clathrin-coated Pit Endocytic Vesicle Membrane Clathrin-coated Vesicle Endocytosis Vesicle-mediated Transport In Synapse Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Budding From Endosome Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Import Into Cell Membrane Membrane Curvature Sensor Activity Vacuolar Transport Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Actin Nucleation Positive Regulation Of Focal Adhesion Disassembly Protein Domain Specific Binding Presynapse Endosome To Melanosome Transport AP-2 Adaptor Complex Golgi To Lysosome Transport Neuronal Ion Channel Clustering Dendritic Spine Maintenance Synapse
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