AP1G1 and SYP

Number of citations of the paper that reports this interaction (PMID 12498786)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		AP1G1	SYP
Gene Name		adaptor-related protein complex 1, gamma 1 subunit	synaptophysin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome	Synaptic Vesicle Cell Junction Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Presynaptic Membrane Neuron Projection Protein Complex Neuron Projection Terminus Presynaptic Active Zone Excitatory Synapse
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding	Transporter Activity Cholesterol Binding Syntaxin-1 Binding Protein Complex Binding SH2 Domain Binding Identical Protein Binding Protein Self-association
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Membrane Organization Golgi To Lysosome Transport	Endocytosis Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Cellular Response To Organic Substance Regulation Of Opioid Receptor Signaling Pathway
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 CLINT1 CLTC DNER KIF13A MAP1A RAB5A RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 ZNF512B	6 interactors: AP1G1 EPOR GRB2 SIAH1 SIAH2 VAMP2
Entrez ID		164	6855
HPRD ID		04637	02435
Ensembl ID		ENSG00000166747	ENSG00000102003
Uniprot IDs		O43747 Q8IY97	B7Z359 P08247
PDB IDs		1IU1
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Localization In Cell Endocytosis Cellular Localization Regulation Of Defense Response To Virus Transport Establishment Of Vesicle Localization Intracellular Protein Transport Vesicle Localization Cellular Protein Localization Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Organelle Localization Vesicle Targeting Vesicle Organization Viral Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Vesicle Targeting, To, From Or Within Golgi Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Immune System Process Regulation Of Endocytosis Synaptic Vesicle Recycling Receptor Internalization Endosomal Transport Negative Regulation Of Kit Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Immune System Process Vesicle Targeting, Trans-Golgi To Endosome Synaptic Vesicle Membrane Organization Regulation Of Synaptic Transmission Membrane Budding Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Endosome Size Regulation Of Opioid Receptor Signaling Pathway	Axon Guidance Post-Golgi Vesicle-mediated Transport Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Response To External Stimulus Erythropoietin-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Degranulation Cell Morphogenesis Involved In Differentiation Regulation Of Exocytosis Golgi To Lysosome Transport Eosinophil Degranulation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cellular Response To Erythropoietin Placenta Development Nervous System Development Vesicle Organization Cellular Response To Insulin Stimulus Neuron Development Cell Morphogenesis Response To Stimulus Golgi Vesicle Transport Golgi To Vacuole Transport Neuron Differentiation Cell Projection Organization Pigment Granule Maturation Endosome To Melanosome Transport Response To Insulin Single Organism Reproductive Process Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Pigment Accumulation Branching Involved In Labyrinthine Layer Morphogenesis Locomotion Cellular Response To Peptide Reproductive Process Developmental Process Regulation Of Signaling Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Lymphocyte Activation Movement Of Cell Or Subcellular Component Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Generation Of Neurons Cell Differentiation Positive Regulation Of Regulated Secretory Pathway
Tagcloud ?			2h3 accessory aggregation associate coprecipitated dephosphorylated epsilonri fc homology ige immunoreceptor mast phosphatases phosphorylated precipitated ptp1 ptp1c ptp1d ptp2 ptp2c rbl reciprocal sh shp src syk synthetic tyrosine unlike
Tagcloud (Difference) ?			2h3 accessory aggregation associate coprecipitated dephosphorylated epsilonri fc homology ige immunoreceptor mast phosphatases phosphorylated precipitated ptp1 ptp1c ptp1d ptp2 ptp2c rbl reciprocal sh shp src syk synthetic tyrosine unlike
Tagcloud (Intersection) ?