MTMR2 and SNTA1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		MTMR2	SNTA1
Description		myotubularin related protein 2	syntrophin alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Vacuolar Membrane Cytosol Synaptic Vesicle Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Cell Projection Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Negative Regulation Of Receptor Internalization Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Myelination Negative Regulation Of Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Appendicular lean mass ( 33097823) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)	HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)
Interacting Genes		7 interacting genes: ERBB3 ERBB4 NEFL ROR2 RSPH1 SBF1 SNTA1	76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6
Entrez ID		8898	6640
HPRD ID		04650	03009
Ensembl ID		ENSG00000087053	ENSG00000101400
Uniprot IDs		Q13614	B3KTR0 Q13424
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR 5GNH
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Neuromuscular Junction Regulation Of Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Lateral Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Central Nervous System Morphogenesis Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Presynaptic Intermediate Filament Cytoskeleton Spermatid Development Neuron Apoptotic Process Epidermal Growth Factor Receptor Activity Regeneration Neurofilament Bundle Assembly Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Radial Spoke Head 1 Radial Spoke Head 3 Kinase Activity Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Postsynaptic Intermediate Filament Cytoskeleton Syntrophin Complex Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Neuron Apoptotic Process ERBB2-ERBB4 Signaling Pathway Regulation Of Axon Diameter Radial Spoke Head ERBB4-ERBB4 Signaling Pathway Response To Sodium Arsenite Germ Cell Development Positive Regulation Of Epithelial Cell Proliferation Schwann Cell Differentiation Response To Wounding	Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process
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