MTMR2 and SBF1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MTMR2	SBF1
Description		myotubularin related protein 2	SET binding factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Vacuolar Membrane Cytosol Synaptic Vesicle Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Cell Projection Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Body Cell Projection Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity
	Biological Process	Negative Regulation Of Receptor Internalization Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Myelination Negative Regulation Of Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process	Protein Dephosphorylation Spermatogenesis Spermatid Development
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane	Synthesis of PIPs at the ER membrane RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Appendicular lean mass ( 33097823) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		7 interacting genes: ERBB3 ERBB4 NEFL ROR2 RSPH1 SBF1 SNTA1	7 interacting genes: AATK HSPB1 KMT2A MTMR2 PDPK1 SUV39H1 TNFSF11
Entrez ID		8898	6305
HPRD ID		04650	06788
Ensembl ID		ENSG00000087053	ENSG00000100241
Uniprot IDs		Q13614	A0A8J8YTQ8 O95248
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR 5GNH
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Neuromuscular Junction Regulation Of Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Lateral Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Central Nervous System Morphogenesis Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Presynaptic Intermediate Filament Cytoskeleton Spermatid Development Neuron Apoptotic Process Epidermal Growth Factor Receptor Activity Regeneration Neurofilament Bundle Assembly Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Radial Spoke Head 1 Radial Spoke Head 3 Kinase Activity Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Postsynaptic Intermediate Filament Cytoskeleton Syntrophin Complex Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Neuron Apoptotic Process ERBB2-ERBB4 Signaling Pathway Regulation Of Axon Diameter Radial Spoke Head ERBB4-ERBB4 Signaling Pathway Response To Sodium Arsenite Germ Cell Development Positive Regulation Of Epithelial Cell Proliferation Schwann Cell Differentiation Response To Wounding	Cellular Response To Growth Factor Stimulus Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Development Negative Regulation Of Protein Kinase C Signaling Response To Growth Factor Regulation Of Canonical NF-kappaB Signal Transduction Cell Development 3-phosphoinositide-dependent Protein Kinase Activity Nitric-oxide Synthase Complex Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Nitrite Reductase (NO-forming) Activity Regulation Of Protein Kinase C Signaling Positive Regulation Of Vasculature Development Regulation Of Endothelial Cell Migration Positive Regulation Of Angiogenesis Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Developmental Process T-helper 2 Cell Differentiation Anatomical Structure Homeostasis Tissue Homeostasis Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Methyltransferase Activity Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Methylation Hemopoiesis Multicellular Organismal-level Homeostasis Circadian Rhythm Regulation Of Heterochromatin Formation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium-mediated Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Histone H3K9 Trimethyltransferase Activity Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose RDNA Heterochromatin Formation ENoSc Complex RDNA Heterochromatin Tooth Eruption Positive Regulation Of Osteoclast Development Positive Regulation Of Fever Generation
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