MTMR2 and ERBB3

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		MTMR2	ERBB3
Description		myotubularin related protein 2	erb-b2 receptor tyrosine kinase 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Vacuolar Membrane Cytosol Synaptic Vesicle Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Cell Projection Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane	Extracellular Region Extracellular Space Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Receptor Internalization Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Myelination Negative Regulation Of Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process	Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Schwann Cell Development Cranial Nerve Development Neuron Differentiation ERBB2-ERBB3 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs			Tucatinib
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Type I diabetes mellitus Lethal congenital contractural syndrome (LCCS)
GWAS		Appendicular lean mass ( 33097823) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)	Age at first sexual intercourse ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Body mass index ( 32700739) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Smoking initiation ( 33082346 30617275) Type 1 diabetes ( 17554300 18198356 18978792 19430480 21829393 30572963 17554260) Vitiligo ( 22951725)
Interacting Genes		7 interacting genes: ERBB3 ERBB4 NEFL ROR2 RSPH1 SBF1 SNTA1	196 interacting genes: ABL1 ABL2 ACYP1 AGTR2 ALDOA ATP5ME BCAR3 BEND5 BLK BLNK BTK CALM1 CD82 CDC25C CDK5 CFL1 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DYRK1A EGF EGFR EGR1 ENOPH1 ERBB2 ERBB4 ERG28 EYA4 EZR FAM241B FER FES FGFR1 FGR FHL3 FKBP1A FLNA FLYWCH1 GABARAPL1 GABARAPL2 GRAP2 GRB2 GRB7 HCK HDAC6 HINT1 HSH2D HSPA1A HSPA8 IL6ST ILKAP INPPL1 IRF2BP2 ITK JAK2 JAK3 JUP LAMTOR2 LBHD1 LCK LCP2 LRRC7 LYN MAP1B MATK MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 MYCBP MYCBP2 NCK1 NCK2 NDUFAB1 NEDD4 NRG1 NRG2 NSMCE1 ODF2L PA2G4 PDGFRA PFDN2 PFDN4 PHPT1 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PPM1K PPM1M PRDX5 PRKACA PRRG4 PSMA5 PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RALGAPA1 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 RTN4 RWDD2A S100A10 SAP18 SELENOK SF3B6 SH2B1 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNCA SNRPB2 SOCS2 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SRC SRPK2 STAP1 STYX SYK SYNM TBCA TCEA2 TEC TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TPTE TRIR TVP23B TXK TXN TXNL4A VAV1 VAV2 VAV3 VTA1 WRNIP1 YES1 YWHAZ ZAP70 ZNF207 ZNF532
Entrez ID		8898	2065
HPRD ID		04650	01820
Ensembl ID		ENSG00000087053	ENSG00000065361
Uniprot IDs		Q13614	P21860
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR 5GNH	1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6KBI 6OP9 7BHE 7BHF 7D85 7MN5 7MN6 7MN8
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Neuromuscular Junction Regulation Of Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Lateral Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Central Nervous System Morphogenesis Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Presynaptic Intermediate Filament Cytoskeleton Spermatid Development Neuron Apoptotic Process Epidermal Growth Factor Receptor Activity Regeneration Neurofilament Bundle Assembly Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Radial Spoke Head 1 Radial Spoke Head 3 Kinase Activity Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Postsynaptic Intermediate Filament Cytoskeleton Syntrophin Complex Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Neuron Apoptotic Process ERBB2-ERBB4 Signaling Pathway Regulation Of Axon Diameter Radial Spoke Head ERBB4-ERBB4 Signaling Pathway Response To Sodium Arsenite Germ Cell Development Positive Regulation Of Epithelial Cell Proliferation Schwann Cell Differentiation Response To Wounding	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity ERBB Signaling Pathway Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Phosphate-containing Compound Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Tyrosine Phosphatase Activity Dephosphorylation Regulation Of Immune Response Cell Activation Leukocyte Activation Cytoplasm Antigen Receptor-mediated Signaling Pathway Protein Phosphorylation Protein Modification Process Immune Response-activating Signaling Pathway Regulation Of Cell Adhesion Protein Kinase Activity Positive Regulation Of Signal Transduction Phosphorylation Immune Response-regulating Signaling Pathway Protein Dephosphorylation Positive Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell Migration Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Regulation Of Immune System Process
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