TAX1BP1 and CBX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TAX1BP1	CBX8
Description		Tax1 binding protein 1	chromobox 8
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GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Cytosol Cytoplasmic Vesicle Extracellular Exosome	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Metal Ion Binding	Chromatin Binding Single-stranded RNA Binding Protein Binding Histone H3K27me3 Reader Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagy Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein K48-linked Ubiquitination Protein Localization To Phagocytic Vesicle Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Cellular Response To Hydrogen Peroxide
Pathways		Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		72 interacting genes: ARHGAP1 ARK2N AZI2 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN ENTREP1 FAM161A FAM168A FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LITAF LMO3 LNX1 LRATD2 MAP1LC3C MRPL11 MRPL53 MYO6 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RIPK1 RNF11 RNF26 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446	92 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-3A H3-4 H3C1 H3C14 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RNF2 RPGRIP1 SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 TXNIP UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1
Entrez ID		8887	57332
HPRD ID		05618	13006
Ensembl ID		ENSG00000106052	ENSG00000141570
Uniprot IDs		B4DSG5 Q86VP1	Q9HC52
PDB IDs		2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G 8W6A 8W6B	2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein Binding Autophagosome Autophagosome Maturation Protein-containing Complex Disassembly Autophagosome Membrane Cytoplasm Modification-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Tag Activity Autophagy GABA Receptor Binding Autophagosome Assembly Regulation Of Canonical NF-kappaB Signal Transduction Macroautophagy Autophagosome Organization Mitophagy Ubiquitin Protein Ligase Activity Cellular Response To Starvation WW Domain Binding Post-translational Protein Modification Protein Ubiquitination Autophagy Of Mitochondrion Catabolic Process Regulation Of Protein Modification Process Signaling Adaptor Activity Response To Starvation Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Beta-tubulin Binding Regulation Of Primary Metabolic Process Cellular Response To Nutrient Levels Organelle Assembly Vacuole Organization Identical Protein Binding Zinc Ion Binding Cytosol Positive Regulation Of Protein Modification Process	Protein Binding Chromatin Organization Cytoskeleton Chromatin Remodeling Cytoplasm PRC1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone H4K16 Acetyltransferase Activity PcG Protein Complex Cytosol Epigenetic Regulation Of Gene Expression Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Zinc Ion Binding Negative Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Metabolic Process Microtubule Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Autophagy Positive Regulation Of Protein Modification Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Centrosome Histone Acetyltransferase Complex CBM Complex Regulation Of Metabolic Process Organelle Organization Cellular Component Assembly Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Autophagy Nucleoplasm Regulation Of Transcription By RNA Polymerase II Microtubule Binding Organelle Assembly Nucleosome Sex Chromatin
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