TAX1BP1 and ARK2N

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TAX1BP1	ARK2N
Description		Tax1 binding protein 1	arkadia (RNF111) N-terminal like PKA signaling regulator 2N
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Cytosol Cytoplasmic Vesicle Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Metal Ion Binding	Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagy Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein K48-linked Ubiquitination Protein Localization To Phagocytic Vesicle Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Release From Viral Latency Negative Regulation Of DNA-templated Transcription Negative Regulation Of Viral Life Cycle
Pathways		Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)
Interacting Genes		72 interacting genes: ARHGAP1 ARK2N AZI2 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN ENTREP1 FAM161A FAM168A FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LITAF LMO3 LNX1 LRATD2 MAP1LC3C MRPL11 MRPL53 MYO6 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RIPK1 RNF11 RNF26 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446	15 interacting genes: DDIT4L ERG JAKMIP1 LRRK2 MCRS1 MORC3 RNF4 SRPK1 SRPK2 SUMO1 SUMO1P1 SUMO2 TAX1BP1 UBC UBE2I
Entrez ID		8887	147339
HPRD ID		05618	12690
Ensembl ID		ENSG00000106052	ENSG00000152242
Uniprot IDs		B4DSG5 Q86VP1	Q96B23
PDB IDs		2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G 8W6A 8W6B
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein Binding Autophagosome Autophagosome Maturation Protein-containing Complex Disassembly Autophagosome Membrane Cytoplasm Modification-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Tag Activity Autophagy GABA Receptor Binding Autophagosome Assembly Regulation Of Canonical NF-kappaB Signal Transduction Macroautophagy Autophagosome Organization Mitophagy Ubiquitin Protein Ligase Activity Cellular Response To Starvation WW Domain Binding Post-translational Protein Modification Protein Ubiquitination Autophagy Of Mitochondrion Catabolic Process Regulation Of Protein Modification Process Signaling Adaptor Activity Response To Starvation Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Beta-tubulin Binding Regulation Of Primary Metabolic Process Cellular Response To Nutrient Levels Organelle Assembly Vacuole Organization Identical Protein Binding Zinc Ion Binding Cytosol Positive Regulation Of Protein Modification Process	Protein Modification Process PML Body Protein Tag Activity Protein Metabolic Process Presynaptic Cytosol Protein Sumoylation Nuclear Body Organization Transcription Factor Binding Protein Modification By Small Protein Conjugation Ubiquitin-like Protein Ligase Binding Postsynaptic Cytosol Post-translational Protein Modification Macromolecule Metabolic Process Small Protein Activating Enzyme Binding Protein Phosphorylation Phosphorylation RNA Binding PML Body Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Nucleus Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Body Positive Regulation Of Viral Genome Replication Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Magnesium Ion Binding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Peptidyl-serine Phosphorylation SUMO Conjugating Enzyme Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Glutamatergic Synapse Negative Regulation Of Intracellular Transport Positive Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Protein Localization To Phagocytic Vesicle Negative Regulation Of Late Endosome To Lysosome Transport Amphisome
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