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TAX1BP1 and ORC5
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
TAX1BP1
ORC5
Gene Name
Tax1 (human T-cell leukemia virus type I) binding protein 1
origin recognition complex, subunit 5
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Extracellular Vesicular Exosome
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Cytoplasm
Molecular Function
Protein Binding
Kinase Binding
Nucleotide Binding
Molecular_function
DNA Replication Origin Binding
Protein Binding
ATP Binding
Biological Process
Apoptotic Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Negative Regulation Of Apoptotic Process
Innate Immune Response
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Negative regulators of RIG-I/MDA5 signaling
Innate Immune System
G2/M Checkpoints
Activation of the pre-replicative complex
Activation of the pre-replicative complex
Orc1 removal from chromatin
Assembly of the pre-replicative complex
Activation of ATR in response to replication stress
G1/S Transition
Assembly of the ORC complex at the origin of replication
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
E2F mediated regulation of DNA replication
Synthesis of DNA
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
S Phase
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Orc1 removal from chromatin
E2F-enabled inhibition of pre-replication complex formation
Cell Cycle Checkpoints
Association of licensing factors with the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions
40 interactors:
ARHGAP1
CALCOCO2
CNTN2
COG7
CWF19L2
CXXC1
DAZAP2
DSTN
EMILIN1
FAM168A
FAM189A2
FOXC2
GABARAP
IKBKG
KIF5B
LGALS8
LMO3
MAP1LC3B
MAP1LC3C
MRPL11
MRPL53
MYO6
NMRK1
ORC5
PLEKHN1
RAB18
RAD18
RIPK1
RNF11
SSX2
STARD13
TBC1D17
TCEA2
TNFAIP3
TNIP1
TNIP3
TRAF6
TSG101
TSHZ3
UBC
29 interactors:
CALCOCO2
CDC45
CDC5L
CDC6
CDC7
DBF4
DMRTA1
HIST3H3
HIST4H4
KRT18
LAMB2
MCM2
MCM3
MCM4
MCM5
MCM7
NIF3L1
NONO
ORC1
ORC2
ORC3
ORC4
ORC6
RPA2
SIPA1L2
STAB1
TAX1BP1
TXNDC11
UBQLN4
Entrez ID
8887
5001
HPRD ID
05618
09086
Ensembl ID
ENSG00000106052
ENSG00000164815
Uniprot IDs
A4D196
B4DSG5
Q86VP1
A4D0P7
O43913
Q53FC8
PDB IDs
Enriched GO Terms of Interacting Partners
?
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
MyD88-independent Toll-like Receptor Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Organelle Disassembly
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Nucleophagy
Immune Response-regulating Signaling Pathway
JNK Cascade
Cellular Response To Stress
Mitochondrion Degradation
Regulation Of Vascular Wound Healing
Regulation Of Type I Interferon Production
Stress-activated MAPK Cascade
Negative Regulation Of Intracellular Signal Transduction
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Autophagic Vacuole Assembly
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Activation Of MAPK Activity
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Macroautophagy
Regulation Of Signaling
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Autophagy
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Viral Protein Processing
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Intracellular Receptor Signaling Pathway
Positive Regulation Of Type I Interferon Production
Membrane Organization
G1/S Transition Of Mitotic Cell Cycle
DNA Replication Initiation
Mitotic Cell Cycle Phase Transition
DNA Replication
Cell Cycle Phase Transition
DNA-dependent DNA Replication
DNA Metabolic Process
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cell Cycle
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Cell Cycle Process
DNA Duplex Unwinding
DNA Geometric Change
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
DNA Conformation Change
Biosynthetic Process
DNA Unwinding Involved In DNA Replication
Double-strand Break Repair Via Break-induced Replication
Chromosome Organization
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Protein-DNA Complex Assembly
Positive Regulation Of Cell Cycle Phase Transition
Cellular Response To Stress
Cellular Response To DNA Damage Stimulus
DNA Replication Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle Checkpoint
DNA Recombination
Cellular Metabolic Process
Regulation Of Cell Cycle Process
Response To Stress
Nuclear DNA Replication
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle G1/S Phase Transition
Cellular Response To Epidermal Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Tagcloud
?
100nm
48h
81m
anapc13
calm2
carcinogenic
diarrheic
drawing
exhaustive
explanation
hn1
malat1
mapre2
mllt11
molluscs
oa
okadaic
pathologies
poisoning
positives
pttg1
rodents
sga
shellfish
shsy5y
ssh
subtractive
toxins
tumourigenesis
Tagcloud (Difference)
?
100nm
48h
81m
anapc13
calm2
carcinogenic
diarrheic
drawing
exhaustive
explanation
hn1
malat1
mapre2
mllt11
molluscs
oa
okadaic
pathologies
poisoning
positives
pttg1
rodents
sga
shellfish
shsy5y
ssh
subtractive
toxins
tumourigenesis
Tagcloud (Intersection)
?