CBX8 and GPRASP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CBX8	GPRASP2
Description		chromobox 8	G protein-coupled receptor associated sorting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Single-stranded RNA Binding Protein Binding Histone H3K27me3 Reader Activity Ubiquitin-protein Transferase Activator Activity	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Cellular Response To Hydrogen Peroxide	Hematopoietic Stem Cell Homeostasis
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		92 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-3A H3-4 H3C1 H3C14 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RNF2 RPGRIP1 SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 TXNIP UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1	52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 DSCR9 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688
Entrez ID		57332	114928
HPRD ID		13006	06612
Ensembl ID		ENSG00000141570	ENSG00000158301
Uniprot IDs		Q9HC52	B3KW05 Q96D09
PDB IDs		2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?		Protein Binding Chromatin Organization Cytoskeleton Chromatin Remodeling Cytoplasm PRC1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone H4K16 Acetyltransferase Activity PcG Protein Complex Cytosol Epigenetic Regulation Of Gene Expression Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Zinc Ion Binding Negative Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Metabolic Process Microtubule Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Autophagy Positive Regulation Of Protein Modification Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Centrosome Histone Acetyltransferase Complex CBM Complex Regulation Of Metabolic Process Organelle Organization Cellular Component Assembly Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Autophagy Nucleoplasm Regulation Of Transcription By RNA Polymerase II Microtubule Binding Organelle Assembly Nucleosome Sex Chromatin	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Trans-synaptic Signaling G Protein-coupled Acetylcholine Receptor Activity Synaptic Signaling Neuromuscular Synaptic Transmission Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Export From Nucleus Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Microtubule Cytoskeleton Organization Cholinergic Synapse Dendrite
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