CBX8 and JAKMIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBX8	JAKMIP1
Description		chromobox 8	janus kinase and microtubule interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Cytoplasm Cytoskeleton Microtubule Membrane Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Single-stranded RNA Binding Protein Binding Histone H3K27me3 Reader Activity Ubiquitin-protein Transferase Activator Activity	RNA Binding Protein Binding Microtubule Binding Kinase Binding GABA Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Cellular Response To Hydrogen Peroxide	Protein Transport Cognition
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)	Coronary artery disease in type 1 diabetes ( 29695241) Response to angiotensin II receptor blocker therapy ( 22566498) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Tau burden ( 33426524)
Interacting Genes		92 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-3A H3-4 H3C1 H3C14 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RNF2 RPGRIP1 SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 TXNIP UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1	21 interacting genes: ARK2N BLK CBX8 CHRM3 DDX6 DSCR9 ENKD1 FXR1 GABBR1 IL16 JAK1 MCRS1 MRPL11 PSMB1 SCNM1 TSGA10IP TYK2 USP2 YES1 YWHAG ZNHIT2
Entrez ID		57332	152789
HPRD ID		13006	11292
Ensembl ID		ENSG00000141570	ENSG00000152969
Uniprot IDs		Q9HC52	B3KWB6 Q96N16
PDB IDs		2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?		Protein Binding Chromatin Organization Cytoskeleton Chromatin Remodeling Cytoplasm PRC1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone H4K16 Acetyltransferase Activity PcG Protein Complex Cytosol Epigenetic Regulation Of Gene Expression Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Zinc Ion Binding Negative Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Metabolic Process Microtubule Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Autophagy Positive Regulation Of Protein Modification Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Centrosome Histone Acetyltransferase Complex CBM Complex Regulation Of Metabolic Process Organelle Organization Cellular Component Assembly Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Autophagy Nucleoplasm Regulation Of Transcription By RNA Polymerase II Microtubule Binding Organelle Assembly Nucleosome Sex Chromatin	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT
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