TAX1BP1 and KIF5B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TAX1BP1	KIF5B
Description		Tax1 binding protein 1	kinesin family member 5B
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GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Cytosol Cytoplasmic Vesicle Extracellular Exosome	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Endocytic Vesicle Nuclear Membrane Vesicle Dendrite Cytoplasm Centriolar Satellite Ciliary Rootlet Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Cytolytic Granule Membrane Axon Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Metal Ion Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Identical Protein Binding Protein-containing Complex Binding Cadherin Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagy Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein K48-linked Ubiquitination Protein Localization To Phagocytic Vesicle Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Microtubule-based Movement Cytoplasm Organization Axon Guidance Positive Regulation Of Synaptic Transmission, GABAergic Lysosome Localization Stress Granule Disassembly Natural Killer Cell Mediated Cytotoxicity Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Vesicle Transport Along Microtubule Mitochondrion Transport Along Microtubule Synaptic Vesicle Transport Centrosome Localization Cellular Response To Type II Interferon Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Anterograde Axonal Protein Transport Mitocytosis Positive Regulation Of Protein Localization To Plasma Membrane Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)	Anti-saccade response ( 29064472) Bipolar disorder with mood-incongruent psychosis ( 23092984) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycine levels ( 30837465) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		72 interacting genes: ARHGAP1 ARK2N AZI2 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN ENTREP1 FAM161A FAM168A FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LITAF LMO3 LNX1 LRATD2 MAP1LC3C MRPL11 MRPL53 MYO6 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RIPK1 RNF11 RNF26 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446	37 interacting genes: APC BAG4 CCDC136 CDC5L CDR2 CEBPA DTNB FHL2 GCC1 GSK3B HSF2BP KIF5A KLC3 KTN1 LBX1 MEOX2 MYO5A NCOA2 NDRG1 POLR2G POU6F2 PRKAR1B PRKAR2B RAPGEF2 RRBP1 SCGN SNAP23 SNAP25 SUMO2 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAQ YWHAZ ZBTB8A
Entrez ID		8887	3799
HPRD ID		05618	07214
Ensembl ID		ENSG00000106052	ENSG00000170759
Uniprot IDs		B4DSG5 Q86VP1	P33176 Q6P164 V9HW29
PDB IDs		2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G 8W6A 8W6B	1BG2 1MKJ 2P4N 3J8X 3J8Y 4HNA 4LNU 5LT0 5LT1 5LT2 5LT3 5LT4 6OJQ 7RIK 8IXA 8IXB 8IXD 8IXE 8IXF 8IXG 8RHB 8RHH 8RIK 8RIZ 9GNQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein Binding Autophagosome Autophagosome Maturation Protein-containing Complex Disassembly Autophagosome Membrane Cytoplasm Modification-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Tag Activity Autophagy GABA Receptor Binding Autophagosome Assembly Regulation Of Canonical NF-kappaB Signal Transduction Macroautophagy Autophagosome Organization Mitophagy Ubiquitin Protein Ligase Activity Cellular Response To Starvation WW Domain Binding Post-translational Protein Modification Protein Ubiquitination Autophagy Of Mitochondrion Catabolic Process Regulation Of Protein Modification Process Signaling Adaptor Activity Response To Starvation Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Beta-tubulin Binding Regulation Of Primary Metabolic Process Cellular Response To Nutrient Levels Organelle Assembly Vacuole Organization Identical Protein Binding Zinc Ion Binding Cytosol Positive Regulation Of Protein Modification Process	Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Postsynapse Secretory Granule Localization CAMP Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Localization To Centrosome Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Intracellular Protein Localization Neuron Projection Establishment Of Vesicle Localization Vesicle CAMP-dependent Protein Kinase Regulator Activity Protein Targeting Phosphoserine Residue Binding Kinesin Binding Protein Sequestering Activity Perinuclear Region Of Cytoplasm Cytoplasm Negative Regulation Of Protein Localization To Nucleus Presynapse Ciliary Rootlet Vesicle Localization Dense Core Granule Cytoskeletal Transport Hippocampal Mossy Fiber To CA3 Synapse Positive Regulation Of Protein Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Cytoskeletal Trafficking Vesicle Fusion To Plasma Membrane Beta-catenin Destruction Complex Regulation Of Protein Localization To Centrosome Focal Adhesion Establishment Of Organelle Localization Intracellular Signal Transduction Establishment Of Protein Localization Wnt Signalosome Negative Regulation Of Calcineurin-NFAT Signaling Cascade Synaptic Vesicle Membrane Organization Cadherin Binding Synaptic Vesicle Priming Regulation Of Protein Localization Negative Regulation Of Signal Transduction Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Synapse TOR Signaling
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