CBX8 and MLLT1

Number of citations of the paper that reports this interaction (PMID 15856011)
23

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (two hybrid, in vivo, in vitro)

		CBX8	MLLT1
Gene Name		chromobox homolog 8	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Transcription Elongation Factor Complex
	Molecular Function	Single-stranded RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Methylated Histone Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Histone Ubiquitination	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		42 interactors: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 HAP1 HIST3H3 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PHC2 PNMA2 RING1 RNF2 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14	9 interactors: AFF1 AFF4 ARID1A CBX8 HIST1H1B HIST3H3 MLLT10 PAF1 WDR5
Entrez ID		57332	4298
HPRD ID		13006	15933
Ensembl ID
Uniprot IDs		Q9HC52	Q03111
PDB IDs		3I91
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Histone Modification Chromatin Modification Chromosome Organization Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Ubiquitination Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Histone H2A Monoubiquitination Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Histone H2A Ubiquitination Peptidyl-lysine Modification Regulation Of Metabolic Process Histone Monoubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Organelle Organization Histone Acetylation Protein Modification By Small Protein Conjugation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Monoubiquitination Anterior/posterior Pattern Specification Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Segment Specification Cellular Protein Modification Process Cellular Response To Reactive Oxygen Species	Chromosome Organization Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Histone Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification RNA Metabolic Process Nucleosome Mobilization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Optic Cup Formation Involved In Camera-type Eye Development Regulation Of Protein Stability Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Optic Cup Morphogenesis Involved In Camera-type Eye Development Glucocorticoid Receptor Signaling Pathway Histone H2B Ubiquitination Biosynthetic Process
Tagcloud ?		aims approaches beings blotting causes chromobox colon conclude cultured express facilitating hct116 homolog igf1 igf1r knockdown leading line overexpression pathogenesis proliferation promote promoting real reports rt silencing unclear western	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Difference) ?		aims approaches beings blotting causes chromobox colon conclude cultured express facilitating hct116 homolog igf1 igf1r knockdown leading line overexpression pathogenesis proliferation promote promoting real reports rt silencing unclear western	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Intersection) ?